Efficient chemoenzymatic synthesis of UDP-α-6-N3-glucose

  • Bioorg Med Chem Lett. 2019 May 1;29(9):1148-1151. doi: 10.1016/j.bmcl.2019.02.002.
Jiajia Wang  1 ,  Dongzhe Zhang  2 ,  Yinhang Wen  2 ,  Xuefeng Cao  3 ,  Jing Ma  4 ,  Peng George Wang  5
Affiliations
  • 1. School of Basic Medical Sciences, Henan University Joint National Laboratory for Antibody Drug Engineering, Kaifeng, Henan 475004, People's Republic of China; Department of Chemistry and Center of Diagnostics & Therapeutics, Georgia State University, 50 Decatur St SE, Atlanta, GA 30303, United States.
  • 2. School of Basic Medical Sciences, Henan University Joint National Laboratory for Antibody Drug Engineering, Kaifeng, Henan 475004, People's Republic of China.
  • 3. Department of Chemistry and Center of Diagnostics & Therapeutics, Georgia State University, 50 Decatur St SE, Atlanta, GA 30303, United States.
  • 4. Institute of Chemical Biology, College of Pharmacy, Henan University, Kaifeng, People's Republic of China. Electronic address: [email protected].
  • 5. Department of Chemistry and Center of Diagnostics & Therapeutics, Georgia State University, 50 Decatur St SE, Atlanta, GA 30303, United States. Electronic address: [email protected].
PMID: 30826291 DOI: 10.1016/j.bmcl.2019.02.002
Abstract

A novel chemo-enzymatic synthetic method for UDP-α-6-N3-glucose was developed by combining the versatility of chemical synthesis and natural enzyme stereo-selectivity of Bifidobacterium longum (BLUSP). This flexible and efficient platform expanded the substrate scope for UDP-sugars on an improved scale, particularly for UDP-sugar substrates containing bioorthogonal functional groups.

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