Triterpenoids with antiproliferative activities from the twigs and leaves of Melaleuca linariifolia

  • J Asian Nat Prod Res. 2021 Aug;23(8):796-802. doi: 10.1080/10286020.2020.1779708.
Yin-Hua Deng  1 ,  Sha Zhang  2 ,  Wei Hu  3 ,  Wei Wu  2 ,  Chun-Mao Dong  2 ,  Feng-Hua Kang  2 ,  Wen-Xuan Wang  2 ,  De-Kun Chen  2 ,  Kang-Ping Xu  2 ,  Zhen-Xing Zou  2
Affiliations
  • 1. Department of Pharmacy, The First Hospital Affiliated to Hunan Normal University, Changsha 410002, China.
  • 2. Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, China.
  • 3. Department of Pharmaceutical Science, Yiyang Medical college, Yiyang 413000, China.
PMID: 32608251 DOI: 10.1080/10286020.2020.1779708
Abstract

One new pentacyclic triterpenoid, urs-12,16-dien-3-one (1), together with twelve known Pentacyclic Triterpenoids (2‒13), were isolated from the twigs and leaves of Melaleuca linariifolia. Their structures were characterized by their 1D- and 2 D-NMR spectra analysis and mass spectra studies. Furthermore, all isolated compounds were tested the inhibitory effect on proliferation of six human Cancer cell lines in vitro, including NCI-H441, NCI-H460, A549, SKOV3, hela, and caki-1 cells. Among them, compounds 3, 5, 7, 9, 12, and 13 exhibited moderate antiproliferative activities with IC50 values ranging from 3.85 to 33.31 μM.

Keywords
Melaleuca linariifolia; Myrtaceae; antiproliferative activity; pentacyclic triterpenoid.
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