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Cat. No.: HY-139030

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28-O-Acetylbetulin

28-O-Acetylbetulin (Compound 4) is a derivative of Betulin (HY-N0083). 28-O-Acetylbetulin has anticancer activity.

For research use only. We do not sell to patients.

CAS No.: 27686-35-7
Formula: C₃₂H₅₂O₃
Molecular Weight:484.75

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

28-O-Acetylbetulin Chemical Structure

CAS No.: 27686-35-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

28-O-Acetylbetulin (Compound 4) is a derivative of Betulin (HY-N0083). 28-O-Acetylbetulin has anticancer activity^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
518A2	IC₅₀	15.84 μM Compound: 4	Cytotoxicity against human 518A2 cells after 96 hrs by SRB assay Cytotoxicity against human 518A2 cells after 96 hrs by SRB assay	[PMID: 20451375]
8505C	IC₅₀	14.74 μM Compound: 4	Cytotoxicity against human 8505C cells after 96 hrs by SRB assay Cytotoxicity against human 8505C cells after 96 hrs by SRB assay	[PMID: 20451375]
A253 cell line	IC₅₀	12.87 μM Compound: 4	Cytotoxicity against human A253 cells after 96 hrs by SRB assay Cytotoxicity against human A253 cells after 96 hrs by SRB assay	[PMID: 20451375]
A2780	IC₅₀	11.74 μM Compound: 4	Cytotoxicity against human A2780 cells after 96 hrs by SRB assay Cytotoxicity against human A2780 cells after 96 hrs by SRB assay	[PMID: 20451375]
A-431	IC₅₀	12.19 μM Compound: 4	Cytotoxicity against human A431 cells after 96 hrs by SRB assay Cytotoxicity against human A431 cells after 96 hrs by SRB assay	[PMID: 20451375]
A549	IC₅₀	14.37 μM Compound: 4	Cytotoxicity against human A549 cells after 96 hrs by SRB assay Cytotoxicity against human A549 cells after 96 hrs by SRB assay	[PMID: 20451375]
BXPC-3	GI₅₀	4.1 μg/mL Compound: 4	Cytotoxicity against human BxPC3 cells after 48 hrs by SRB assay Cytotoxicity against human BxPC3 cells after 48 hrs by SRB assay	[PMID: 24694263]
DLD-1	IC₅₀	13.12 μM Compound: 4	Cytotoxicity against human DLD1 cells after 96 hrs by SRB assay Cytotoxicity against human DLD1 cells after 96 hrs by SRB assay	[PMID: 20451375]
DU-145	GI₅₀	7.6 μg/mL Compound: 4	Cytotoxicity against human DU145 cells after 48 hrs by SRB assay Cytotoxicity against human DU145 cells after 48 hrs by SRB assay	[PMID: 24694263]
FaDu	IC₅₀	13.95 μM Compound: 4	Cytotoxicity against human FADU cells after 96 hrs by SRB assay Cytotoxicity against human FADU cells after 96 hrs by SRB assay	[PMID: 20451375]
HCT-116	IC₅₀	10.71 μM Compound: 4	Cytotoxicity against human HCT116 cells after 96 hrs by SRB assay Cytotoxicity against human HCT116 cells after 96 hrs by SRB assay	[PMID: 20451375]
HCT-8	IC₅₀	17.98 μM Compound: 4	Cytotoxicity against human HCT8 cells after 96 hrs by SRB assay Cytotoxicity against human HCT8 cells after 96 hrs by SRB assay	[PMID: 20451375]
HT-29	IC₅₀	10.96 μM Compound: 4	Cytotoxicity against human HT-29 cells after 96 hrs by SRB assay Cytotoxicity against human HT-29 cells after 96 hrs by SRB assay	[PMID: 20451375]
KM-20L2	GI₅₀	5 μg/mL Compound: 4	Cytotoxicity against human KM20L2 cells after 48 hrs by SRB assay Cytotoxicity against human KM20L2 cells after 48 hrs by SRB assay	[PMID: 24694263]
MCF7	GI₅₀	3 μg/mL Compound: 4	Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay	[PMID: 24694263]
MCF7	IC₅₀	11.38 μM Compound: 4	Cytotoxicity against human MCF7 cells after 96 hrs by SRB assay Cytotoxicity against human MCF7 cells after 96 hrs by SRB assay	[PMID: 20451375]
NCI-H460	GI₅₀	2.5 μg/mL Compound: 4	Cytotoxicity against human NCI-H460 cells after 48 hrs by SRB assay Cytotoxicity against human NCI-H460 cells after 48 hrs by SRB assay	[PMID: 24694263]
P388	ED₅₀	0.805 μg/mL Compound: 4	Cytotoxicity against mouse P388 cells after 48 hrs Cytotoxicity against mouse P388 cells after 48 hrs	[PMID: 24694263]
SF-268	GI₅₀	4 μg/mL Compound: 4	Cytotoxicity against human SF268 cells after 48 hrs by SRB assay Cytotoxicity against human SF268 cells after 48 hrs by SRB assay	[PMID: 24694263]
SW-1736	IC₅₀	11.95 μM Compound: 4	Cytotoxicity against human SW1736 cells after 96 hrs by SRB assay Cytotoxicity against human SW1736 cells after 96 hrs by SRB assay	[PMID: 20451375]
SW480	IC₅₀	13.68 μM Compound: 4	Cytotoxicity against human SW480 cells after 96 hrs by SRB assay Cytotoxicity against human SW480 cells after 96 hrs by SRB assay	[PMID: 20451375]

Chemical Information

CAS No. 27686-35-7
Molecular Weight 484.75
Formula C₃₂H₅₂O₃
SMILES

CC(OC[C@]12[C@@]([C@@H](CC2)C(C)=C)([H])[C@]3([H])[C@@](CC1)([C@]4([C@]([C@@]5([C@@](C(C)([C@H](CC5)O)C)([H])CC4)C)([H])CC3)C)C)=O
Structure Classification
- Terpenoids
- Triterpenes
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Deng YH, et al. Triterpenoids with antiproliferative activities from the twigs and leaves of Melaleuca linariifolia. J Asian Nat Prod Res. 2021 Aug;23(8):796-802. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
Chemical Information
Purity & Documentation
References

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28-O-Acetylbetulin

High-Throughput Bioactive Compound Library

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

28-O-Acetylbetulin Related Classifications

HY-139030 Related Classifications