Protective effect of scorpion venom heat-resistant synthetic peptide against PM2.5-induced microglial polarization via TLR4-mediated autophagy activating PI3K/AKT/NF-κB signaling pathway

  • J Neuroimmunol. 2021 Jun 15:355:577567. doi: 10.1016/j.jneuroim.2021.577567.
Xin Xu  1 ,  Henggui Xu  1 ,  Fei Ren  1 ,  Lanyi Huang  1 ,  Jingbin Xu  1 ,  Fasheng Li  2
Affiliations
  • 1. College of Medical Laboratory, Dalian Medical University, Dalian 116044, Liaoning Province, China.
  • 2. College of Medical Laboratory, Dalian Medical University, Dalian 116044, Liaoning Province, China; National-Local Joint Engineering Research Center for Drug-Research and Development (R & D) of Neurodegenerative Diseases, Dalian Medical University, Dalian, 116044, Liaoning Province, China. Electronic address: [email protected].
PMID: 33887539 DOI: 10.1016/j.jneuroim.2021.577567
Abstract

There is growing evidence that fine particulate matter (PM2.5) is a considerable risk factor for neurodegenerative diseases. Scorpion venom heat-resistant synthetic peptide (SVHRSP) plays a neuroprotective effect by promoting neurogenesis and neuron axon growth. In this study, SVHRSP inhibited the level of TLR4, Autophagy and PM2.5-induced microglia M1 polarization, thereby promoting Phosphorylation of PI3K and Akt, inhibiting the expression of NF-κB. Moreover, SVHRSP suppressed the cytotoxic factors and increased the cytoprotective factor. This research demonstrates that SVHRSP relieves PM2.5-induced microglial polarization via TLR4-mediated Autophagy activating PI3K/Akt/NF-κB signaling pathway, which provides new insights for the treatment of PM2.5-induced neurodegenerative diseases.

Keywords
Autophagy; PI3K/AKT/NF-κB pathway; PM(2.5); Polarization; Scorpion venom heat-resistant synthetic peptide; TLR4.
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