PINK1: From Parkinson's disease to mitophagy and back again

  • PLoS Biol. 2023 Jun 29;21(6):e3002196. doi: 10.1371/journal.pbio.3002196.
Benjamin O'Callaghan  1  2 ,  John Hardy  1  2  3 ,  Helene Plun-Favreau  1  2
Affiliations
  • 1. Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, United Kingdom.
  • 2. Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, Maryland, United States of America.
  • 3. UCL Dementia Research Institute, London, United Kingdom.
PMID: 37384773 DOI: 10.1371/journal.pbio.3002196
Abstract

The genetics of Parkinson's disease has been key to unravelling the PINK1-dependent Mitophagy process. Here, we discuss the implications of a 2010 PLOS Biology paper that shed light on the functional importance of PINK1 in the Mitophagy cascade.