Development of the core-shell nano-system and its application in infective endocarditis: A non-antibiotic therapeutic strategy

  • Biomater Adv. 2026 Jun 8:188:215001. doi: 10.1016/j.bioadv.2026.215001.
Sishi Cai  1 ,  Chunmei Zhou  2 ,  Zhaoyan Zhou  2 ,  Rong Bao  2 ,  Lijuan Hu  1 ,  Jue Pan  1 ,  Bijie Hu  3 ,  Jiasheng Yin  4
Affiliations
  • 1. Department of Infectious Diseases, Zhongshan Hospital, Fudan University, Shanghai, China.
  • 2. Department of Microbiology, Zhongshan Hospital, Fudan University, Shanghai, China.
  • 3. Department of Infectious Diseases, Zhongshan Hospital, Fudan University, Shanghai, China. Electronic address: [email protected].
  • 4. Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, China. Electronic address: [email protected].
PMID: 42263554 DOI: 10.1016/j.bioadv.2026.215001
Abstract

This study developed a novel core-shell nano-system aimed at addressing the clinical challenges posed by infective endocarditis (IE). The system combines ZIF-8 nanozymes and a polydopamine (PDA) coating, exhibiting excellent biocompatibility, antioxidative, anti-inflammatory, and Antibacterial properties. In vitro experiments demonstrated that the system effectively inhibited the growth of S. aureus and significantly reduced inflammation and oxidative stress induced by Bacterial infection. A mouse model of IE was constructed, and the therapeutic effects of the core-shell nano-system in vivo were assessed via tail vein injection. Experimental results indicated that the system not only significantly reduced the expression of thrombus components but also improved aortic wall cell infiltration and effectively cleared the invading S. aureus. This study provides new insights and methods for non-antibiotic treatment of IE, with significant clinical application potential.

Keywords
Infective endocarditis; NETs; Nanozymes; S. aureus.
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