(R)-(4′-Hydroxy)-5,7-dihydroxy-4-chromanone
(R)-(4′-Hydroxy)-5,7-dihydroxy-4-chromanone, a homoisoflavonoid, has antiangiogenic activity against human retinal microvascular endothelial cells.
For research use only. We do not sell to patients.
- CAS No.: 849727-88-4
- Formula: C16H14O5
- Molecular Weight:286.28
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
>100 μM
Compound: 18
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Cytotoxicity against human A549 cells after 72 hrs by MTT assay
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
|
[PMID: 19689125] |
| B16-BL6 | IC50 |
>100 μM
Compound: 18
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Cytotoxicity against mouse B16-BL6 cells after 72 hrs by MTT assay
Cytotoxicity against mouse B16-BL6 cells after 72 hrs by MTT assay
|
[PMID: 19689125] |
| HeLa | IC50 |
>100 μM
Compound: 18
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Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
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[PMID: 19689125] |
| HT-1080 | IC50 |
>100 μM
Compound: 18
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Cytotoxicity against human HT1080 cells after 72 hrs by MTT assay
Cytotoxicity against human HT1080 cells after 72 hrs by MTT assay
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[PMID: 19689125] |
| HT-29 | IC50 |
>20 μM
Compound: 7
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Cytotoxicity against human HT-29 cells assessed as reduction in cell growth incubated for 72 hrs
Cytotoxicity against human HT-29 cells assessed as reduction in cell growth incubated for 72 hrs
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[PMID: 26147490] |
| HUVEC | GI50 |
>100 μM
Compound: 7; 21
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Antiproliferative activity against HUVEC assessed as reduction in cell number incubated for 44 hrs by alamar blue based fluorescence assay
Antiproliferative activity against HUVEC assessed as reduction in cell number incubated for 44 hrs by alamar blue based fluorescence assay
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[PMID: 30951308] |
| MDA-MB-435 | IC50 |
>20 μM
Compound: 7
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Cytotoxicity against human MDA-MB-435 cells assessed as reduction in cell growth incubated for 72 hrs
Cytotoxicity against human MDA-MB-435 cells assessed as reduction in cell growth incubated for 72 hrs
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[PMID: 26147490] |
| Y79 | GI50 |
>100 μM
Compound: 7; 21
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Cytotoxicity against human Y79 cells assessed as reduction in cell number incubated for 44 hrs by alamar blue based fluorescence assay
Cytotoxicity against human Y79 cells assessed as reduction in cell number incubated for 44 hrs by alamar blue based fluorescence assay
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[PMID: 30951308] |
(R)-(4′-Hydroxy)-5,7-dihydroxy-4-chromanone has an GI50 value of 35.8 μM on proliferation of human retinal microvascular endothelial cells (HRECs)[1].
(R)-(4′-Hydroxy)-5,7-dihydroxy-4-chromanone (10 μM, 30 μM, and 100 μM; 8 hours) significantly decreases HRECs overall tubule formation and in a dose-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 849727-88-4
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Molecular Weight 286.28
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Formula C16H14O5
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SMILES
O=C1[C@H](CC2=CC=C(O)C=C2)COC3=CC(O)=CC(O)=C13
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(R)-(4′-Hydroxy)-5,7-dihydroxy-4-chromanone Related Classifications
HY-N8178 Related Classifications
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