(R)-(4′-Hydroxy)-5,7-dihydroxy-4-chromanone

製品番号: HY-N8178: Data Sheet 取扱説明書
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(R)-(4′-Hydroxy)-5,7-dihydroxy-4-chromanone, a homoisoflavonoid, has antiangiogenic activity against human retinal microvascular endothelial cells.

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(R)-(4′-Hydroxy)-5,7-dihydroxy-4-chromanone 構造式

CAS 番号 : 849727-88-4

容量	価格（税別）	在庫状況
1 mg	$210	見積もりとリードタイムを求めるのご確認
5 mg	$525	見積もりとリードタイムを求めるのご確認
10 mg	$840	見積もりとリードタイムを求めるのご確認

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

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純度とドキュメンテーション
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製品説明

(R)-(4′-Hydroxy)-5,7-dihydroxy-4-chromanone, a homoisoflavonoid, has antiangiogenic activity against human retinal microvascular endothelial cells^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	>100 μM Compound: 18	Cytotoxicity against human A549 cells after 72 hrs by MTT assay Cytotoxicity against human A549 cells after 72 hrs by MTT assay	[PMID: 19689125]
B16-BL6	IC₅₀	>100 μM Compound: 18	Cytotoxicity against mouse B16-BL6 cells after 72 hrs by MTT assay Cytotoxicity against mouse B16-BL6 cells after 72 hrs by MTT assay	[PMID: 19689125]
HeLa	IC₅₀	>100 μM Compound: 18	Cytotoxicity against human HeLa cells after 72 hrs by MTT assay Cytotoxicity against human HeLa cells after 72 hrs by MTT assay	[PMID: 19689125]
HT-1080	IC₅₀	>100 μM Compound: 18	Cytotoxicity against human HT1080 cells after 72 hrs by MTT assay Cytotoxicity against human HT1080 cells after 72 hrs by MTT assay	[PMID: 19689125]
HT-29	IC₅₀	>20 μM Compound: 7	Cytotoxicity against human HT-29 cells assessed as reduction in cell growth incubated for 72 hrs Cytotoxicity against human HT-29 cells assessed as reduction in cell growth incubated for 72 hrs	[PMID: 26147490]
HUVEC	GI₅₀	>100 μM Compound: 7; 21	Antiproliferative activity against HUVEC assessed as reduction in cell number incubated for 44 hrs by alamar blue based fluorescence assay Antiproliferative activity against HUVEC assessed as reduction in cell number incubated for 44 hrs by alamar blue based fluorescence assay	[PMID: 30951308]
MDA-MB-435	IC₅₀	>20 μM Compound: 7	Cytotoxicity against human MDA-MB-435 cells assessed as reduction in cell growth incubated for 72 hrs Cytotoxicity against human MDA-MB-435 cells assessed as reduction in cell growth incubated for 72 hrs	[PMID: 26147490]
Y79	GI₅₀	>100 μM Compound: 7; 21	Cytotoxicity against human Y79 cells assessed as reduction in cell number incubated for 44 hrs by alamar blue based fluorescence assay Cytotoxicity against human Y79 cells assessed as reduction in cell number incubated for 44 hrs by alamar blue based fluorescence assay	[PMID: 30951308]

体外実験

(R)-(4′-Hydroxy)-5,7-dihydroxy-4-chromanone has an GI₅₀ value of 35.8 μM on proliferation of human retinal microvascular endothelial cells (HRECs)^[1].
(R)-(4′-Hydroxy)-5,7-dihydroxy-4-chromanone (10 μM, 30 μM, and 100 μM; 8 hours) significantly decreases HRECs overall tubule formation and in a dose-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

286.28

分子式

C₁₆H₁₄O₅

CAS 番号

849727-88-4

SMILES

O=C1[C@H](CC2=CC=C(O)C=C2)COC3=CC(O)=CC(O)=C13

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Sianne L Schwikkard, et al. Antiangiogenic Activity and Cytotoxicity of Triterpenoids and Homoisoflavonoids from Massonia pustulata and Massonia bifolia. Planta Med. 2018 Jul;84(9-10):638-644. [Content Brief]