ACSS2 Protein, Human (His)
Based on 1 Customer Validation
The ACSS2 protein plays a key role in catalyzing the synthesis of acetyl-CoA from short-chain fatty acids, with acetate being the preferred substrate. Although acetate is efficiently utilized, ACSS2 can also process propionate, albeit with significantly lower affinity. ACSS2 Protein, Human (His) is the recombinant human-derived ACSS2 protein, expressed by E. coli , with N-6*His labeled tag.
- Species: Human
- Source: E. coli
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
The ACSS2 protein plays a key role in catalyzing the synthesis of acetyl-CoA from short-chain fatty acids, with acetate being the preferred substrate. Although acetate is efficiently utilized, ACSS2 can also process propionate, albeit with significantly lower affinity. ACSS2 Protein, Human (His) is the recombinant human-derived ACSS2 protein, expressed by E. coli , with N-6*His labeled tag.
ACSS2 (Acetyl-CoA synthetase 2) is an enzyme that plays a crucial role in cellular metabolism by catalyzing the synthesis of acetyl-CoA from short-chain fatty acids. Acetate is the preferred substrate for ACSS2, and it efficiently converts acetate into acetyl-CoA. This enzymatic activity is pivotal for various cellular processes, including energy production, lipid metabolism, and histone acetylation. ACSS2 can also utilize propionate, albeit with a much lower affinity compared to acetate. The ability of ACSS2 to generate acetyl-CoA from short-chain fatty acids contributes to the pool of acetyl-CoA available for diverse metabolic pathways, emphasizing its importance in cellular energy homeostasis and the integration of metabolic signals.
Technical Parameters
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Species Human
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Source E. coli
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Tag N-6*His
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Accession
Q9NR19-1 (G2-Q701)
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Gene ID55902
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Molecular Construction
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N-term
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6*His
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ACSS2 (G2-Q701)
Accession # Q9NR19-1 -
C-term
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Protein Length
Partial
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Synonyms
ACSS2; Acetyl-Coenzyme A Synthetase 2 (ADP Forming); Prev. ACAS2; Acetyl-CoA Synthetase; AceCS; Acetate--CoA Ligase; ACS; AceCS1; Acetyl-Coenzyme A Synthetase, Cytoplasmic; CDNA FLJ53719, Highly Similar To Acetyl-Coenzyme A Synthetase, Cytoplasmic (EC6.2.
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AA Sequence
GLPEERVRSGSGSRGQEEAGAGGRARSWSPPPEVSRSAHVPSLQRYRELHRRSVEEPREFWGDIAKEFYWKTPCPGPFLRYNFDVTKGKIFIEWMKGATTNICYNVLDRNVHEKKLGDKVAFYWEGNEPGETTQITYHQLLVQVCQFSNVLRKQGIQKGDRVAIYMPMIPELVVAMLACARIGALHSIVFAGFSSESLCERILDSSCSLLITTDAFYRGEKLVNLKELADEALQKCQEKGFPVRCCIVVKHLGRAELGMGDSTSQSPPIKRSCPDVQISWNQGIDLWWHELMQEAGDECEPEWCDAEDPLFILYTSGSTGKPKGVVHTVGGYMLYVATTFKYVFDFHAEDVFWCTADIGWITGHSYVTYGPLANGATSVLFEGIPTYPDVNRLWSIVDKYKVTKFYTAPTAIRLLMKFGDEPVTKHSRASLQVLGTVGEPINPEAWLWYHRVVGAQRCPIVDTFWQTETGGHMLTPLPGATPMKPGSATFPFFGVAPAILNESGEELEGEAEGYLVFKQPWPGIMRTVYGNHERFETTYFKKFPGYYVTGDGCQRDQDGYYWITGRIDDMLNVSGHLLSTAEVESALVEHEAVAEAAVVGHPHPVKGECLYCFVTLCDGHTFSPKLTEELKKQIREKIGPIATPDYIQNAPGLPKTRSGKIMRRVLRKIAQNDHDLGDMSTVADPSVISHLFSHRCLTIQ
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Predicted Molecular Mass
80.5 kDa
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Solution
1.Supplied as a 0.2 μm filtered solution of 50 mM HEPES, pH 7.0, 200 mM NaCl, 20% glycerol, 1 mM DTT.
2.Supplied as a 0.2 μm filtered solution of 50 mM HEPES, pH 7.5, 200 mM NaCl, 20% glycerol, 1 mM DTT.
Please refer to the lot-specific COA for specific buffer information.
<1 EU/μg, determined by LAL method.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
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Data Sheet (239 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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