Alpha-Fetoprotein Protein, Canine (HEK293, His)
Alpha-Fetoprotein binds copper, nickel, and fatty acids, displaying particular affinity for bilirubin, albeit less efficiently than serum albumin. Its structural variations, including dimeric and trimeric forms, alongside the monomeric state, contribute to the protein's versatile functionality. This complexity in molecular interactions with diverse ligands underscores Alpha-Fetoprotein's significance in various physiological processes. Alpha-Fetoprotein Protein, Canine (HEK293, His) is the recombinant canine-derived Alpha-Fetoprotein protein, expressed by HEK293 , with C-His labeled tag.
- Species: Canine
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
Alpha-Fetoprotein binds copper, nickel, and fatty acids, displaying particular affinity for bilirubin, albeit less efficiently than serum albumin. Its structural variations, including dimeric and trimeric forms, alongside the monomeric state, contribute to the protein's versatile functionality. This complexity in molecular interactions with diverse ligands underscores Alpha-Fetoprotein's significance in various physiological processes. Alpha-Fetoprotein Protein, Canine (HEK293, His) is the recombinant canine-derived Alpha-Fetoprotein protein, expressed by HEK293 , with C-His labeled tag.
Background
The Alpha-Fetoprotein Protein exhibits diverse binding capabilities, including the ability to bind copper, nickel, and fatty acids. Notably, it demonstrates affinity for bilirubin, although less efficiently than serum albumin. The protein exists in various forms, with dimeric and trimeric structures identified in addition to the monomeric form. These structural variations likely contribute to the functional versatility of Alpha-Fetoprotein, suggesting a complex interplay in its molecular interactions with different ligands and emphasizing its significance in various physiological processes.
Technical Parameters
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Species Canine
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Source HEK293
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Tag C-8*His
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Accession
Q8MJU5 (R19-V609)
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Molecular Construction
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N-term
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Alpha-Fetoprotein (R19-V609)
Accession # Q8MJU5 -
8*His
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C-term
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Protein Length
Full Length of Mature Protein
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Synonyms
AFP; Alpha-Fetoglobulin; Prev. HPAFP; Fetoglobulin; Alpha-Fetoprotein; AFPD; Alpha-1-Fetoprotein; Alpha Fetoprotein; FETA
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AA Sequence
RTMHRNAYGIASILDSSQCSAEMNLVDLATIFFAQFVQEATYKEVSKMVKDILTVIEKSTGSEQPGGCLENQLPAFLEEICHEKEISEKYGLADCCSQREEERHNCFLAHKKAAPPSIPPFQVAEPVTSCKAYEENRDMFMNRYIYEIARRHPFLYAPTILSLAAHYGKIIPLCCKAENAVECFQTKTSLITKELRESSLLNQHICAVMRNFGPRTFRAITVTKLSQKFSKANFTEIQKLVLDVAHIHEECCRGNVLECLQDGEKIMSYICSQQDILSSKIADCCKLPILELGQCIIHAENDGKPEGLSPNLNRFLEERDFNQFSSREKDLFMARFTYEYSRRHTKLAVPVVLRVAKGYQELLEKCSQSENPLECQDKGEEELEKYIQESQALAKRSCGLFQKLGEYYLQNAFLVAYTKKAPQLTPPELMAFTRKMATAAATCCQLSEDRQLACGEGAADLIIGQLCIRHEETPINPGVGQCCSSSYANRRPCFSSLVVDETYIPSPFSADKFIFHKDLCQAQGVALQTMKQQFLINLVKQKPQITEEQLEAVIADFSGLLEKCCQGQEQEACFEEEGPKLISKTRAALGV
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Predicted Molecular Mass
67.7 kDa
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Molecular Weight
Approximately 68-70 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
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Glycosylation
Yes
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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