B3GNT1 Protein, Human (HEK293, His)
B3GNT1 Protein, Human (HEK293, His) is related to severe Walker–Warburg syndrome (WWS).
- Species: Human
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- References
- Help & FAQs
Biological Activity
Description
B3GNT1 Protein, Human (HEK293, His) is related to severe Walker–Warburg syndrome (WWS)[1].
Technical Parameters
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Species Human
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Source HEK293
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Tag C-6*His
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Accession
O43505 (D43-C415)
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Molecular Construction
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N-term
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B3GNT1 (D43-C415)
Accession # O43505 -
6*His
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C-term
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Protein Length
Partial Extracellular Domain
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Synonyms
B4GAT1; B3GN-T1; Prev. B3GNT1; UDP-GlcNAc:BetaGal Beta-1,3-N-Acetylglucosaminyltransferase 6; Prev. B3GNT6; I-Beta-1,3-N-Acetylglucosaminyltransferase; IGnT; Poly-N-Acetyllactosamine Extension Enzyme; N-Acetyllactosaminide Beta-1,3-N-Acetylglucosaminyltra
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AA Sequence
DQYFEFFPPSPRSVDQVKAQLRTALASGGVLDASGDYRVYRGLLKTTMDPNDVILATHASVDNLLHLSGLLERWEGPLSVSVFAATKEEAQLATVLAYALSSHCPDMRARVAMHLVCPSRYEAAVPDPREPGEFALLRSCQEVFDKLARVAQPGINYALGTNVSYPNNLLRNLAREGANYALVIDVDMVPSEGLWRGLREMLDQSNQWGGTALVVPAFEIRRARRMPMNKNELVQLYQVGEVRPFYYGLCTPCQAPTNYSRWVNLPEESLLRPAYVVPWQDPWEPFYVAGGKVPTFDERFRQYGFNRISQACELHVAGFDFEVLNEGFLVHKGFKEALKFHPQKEAENQHNKILYRQFKQELKAKYPNSPRRC
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Predicted Molecular Mass
43.4 kDa
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Molecular Weight
Approximately 45-55 kDa, based on SDS-PAGE under reducing conditions.
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Glycosylation
Yes
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
References
[1]. Ranad Shaheen, et al. A truncating mutation in B3GNT1 causes severe Walker-Warburg syndrome. Neurogenetics. 2013 Nov;14(3-4):243-5. [Content Brief]
[2]. Franziska Biellmann, et al. Impaired sexual behavior in male mice deficient for the beta1-3 N-acetylglucosaminyltransferase-I gene. Mol Reprod Dev. 2008 May;75(5):699-706. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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