B4GALT3 Protein, Human (HEK293, His)
B4GALT3 Protein, Human (HEK293, His) promotes cell proliferation and invasion in glioblastoma. B4GALT3 plays an important role in development tumourigenesis.
- Species: Human
- Source: HEK293
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- References
- Help & FAQs
Biological Activity
Description
B4GALT3 Protein, Human (HEK293, His) promotes cell proliferation and invasion in glioblastoma. B4GALT3 plays an important role in development tumourigenesis[1].
Background
B4GALT3 is upregulated in glioblastoma and predicts poor prognosis. Upregulation of B4GALT3 promotes GBM cell proliferation and invasion while the downregulation of B4GALT3 reduces GBM cell proliferation and invasion. B4GALT3 regulates cell proliferation and invasion via β-catenin and vimentin. B[1]. B4GALT3 is an enzyme responsible for the generation of poly-N-acetyllactosamine and is involved in tumorigenesis[2].
Technical Parameters
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Species Human
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Source HEK293
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Tag C-6*His
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Accession
O60512 (R32-S392)
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Molecular Construction
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N-term
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B4GALT3 (R32-S392)
Accession # O60512 -
6*His
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C-term
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Protein Length
Lumenal Domain
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Synonyms
B4GALT3; Beta-1,4-GalTase 3; Beta-1,4-Galactosyltransferase 3; Nal Synthase; Beta4Gal-T3; B4Gal-T3; UDP-Galactose:Beta-N-Acetylglucosamine Beta-1,4-Galactosyltransferase 3; Beta-N-Acetylglucosaminyl-Glycolipid Beta-1,4-Galactosyltransferase 3; Beta-N-Acet
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AA Sequence
RSLSALFGRDQGPTFDYSHPRDVYSNLSHLPGAPGGPPAPQGLPYCPERSPLLVGPVSVSFSPVPSLAEIVERNPRVEPGGRYRPAGCEPRSRTAIIVPHRAREHHLRLLLYHLHPFLQRQQLAYGIYVIHQAGNGTFNRAKLLNVGVREALRDEEWDCLFLHDVDLLPENDHNLYVCDPRGPRHVAVAMNKFGYSLPYPQYFGGVSALTPDQYLKMNGFPNEYWGWGGEDDDIATRVRLAGMKISRPPTSVGHYKMVKHRGDKGNEENPHRFDLLVRTQNSWTQDGMNSLTYQLLARELGPLYTNITADIGTDPRGPRAPSGPRYPPGSSQAFRQEMLQRRPPARPGPLSTANHTALRGS
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Predicted Molecular Mass
41.5 kDa
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Molecular Weight
Approximately 50 kDa, based on SDS-PAGE under reducing conditions.
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Glycosylation
Yes
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Solution
<1 EU/μg, determined by LAL method.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
References
[1]. Tao Wu, et al. B4GALT3 promotes cell proliferation and invasion in glioblastoma. Neurol Res. 2020 Jun;42(6):463-470. [Content Brief]
[2]. Yanrui Sun, et al. B4GALT3 up-regulation by miR-27a contributes to the oncogenic activity in human cervical cancer cells. Cancer Lett. 2016 Jun 1;375(2):284-292. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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