BMPR1A/ALK-3 Protein, Human (HEK293, hFc)
BMPR1A/ALK-3 Protein, Human (HEK293, hFc) is the recombinant human-derived BMPR1A/ALK-3 protein, expressed by HEK293, with C-hFc tag.
- Species: Human
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
BMPR1A/ALK-3 Protein, Human (HEK293, hFc) is the recombinant human-derived BMPR1A/ALK-3 protein, expressed by HEK293, with C-hFc tag.
Background
BMPR1A is a transmembrane serine/threonine kinase that forms a receptor complex consisting of two type II and two type I receptors upon ligand binding. Type II receptors phosphorylate and activate type I receptors, which autophosphorylate and subsequently bind and activate SMAD transcriptional regulators. It serves as a receptor for BMP2, BMP4, GDF5, and GDF6, positively regulating chondrocyte differentiation through GDF5 interaction and mediating adipogenesis induction by GDF6. Additionally, it may promote HAMP expression, potentially via its interaction with BMP2 (By similarity).
Technical Parameters
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Species Human
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Source HEK293
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Tag C-hFc
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Accession
P36894 (Q24-R152)
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Gene ID657
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Protein Length
Extracellular Domain
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Synonyms
BMPR1A; BMP Type-1A Receptor; Prev. ACVRLK3; ALK-3; ALK3; SKR5; CD292; Activin A Receptor, Type II-Like Kinase 3; Bone Morphogenetic Protein Receptor, Type IA; Receptor Protein Serine/Threonine Kinase; Bone Morphogenetic Protein Receptor Type-1A; CD292 An
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AA Sequence
QNLDSMLHGTGMKSDSDQKKSENGVTLAPEDTLPFLKCYCSGHCPDDAINNTCITNGHCFAIIEEDDQGETTLASGCMKYEGSDFQCKDSPKAQLRRTIECCRTNLCNQYLQPTLPPVVIGPFFDGSIR
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Predicted Molecular Mass
40.9 kDa
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Molecular Weight
Approximately 56 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
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Glycosylation
Yes
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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