C6/Complement component C6 Protein, Human (HEK293, His)

C6/Complement component C6 Protein is a part of the lytic membrane attack complex formed during complement activation, which has an indispensable role in innate and acquired immune responses by forming pores in the plasma membrane of target cells, as well as cancer immune surveillance. It is a component of the complement cascade which can be incorporated into the cell membrane and cause cell lysis. People with C6 deficiency are prone to bacterial infection. C6/Complement component C6 Protein, Human (HEK293, His) is the recombinant human-derived C6/Complement component C6 protein, expressed by HEK293 , with C-His labeled tag. The total length of C6/Complement component C6 Protein, Human (HEK293, His) is 934 a.a., with molecular weight of ~110 kDa.

Complement component C6 (C6) is a part of the lytic membrane attack complex formed during complement activation, which has an indispensable role in innate and acquired immune responses by forming pores in the plasma membrane of target cells, as well as cancer immune surveillance. It is a component of the complement cascade which can be incorporated into the cell membrane and cause cell lysis. Purified human C6 is unique to the terminal complement pathway and also plays a critical role in inflammatory responses. C6 deficiency is the most common terminal complement component deficiency and can present later in age with N. meningitidis infections^[1][2].

Human

HEK293

C-His

AAA59668 (M1-A934)

729  [NCBI]

Approximately 110 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.