CLC1 Protein, Human (HEK293)
CLC1 Protein, Human (HEK293) is the recombinant human-derived CLC1, expressed by HEK293 , with tag Free labeled tag.
- Species: Human
- Source: HEK293
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
Description
CLC1 Protein, Human (HEK293) is the recombinant human-derived CLC1, expressed by HEK293 , with tag Free labeled tag.
Background
CLC1 is a voltage-gated chloride channel that plays a key role in skeletal muscle excitability. It generates the majority of plasma membrane chloride conductance in skeletal muscle fibers, stabilizing the resting membrane potential and contributing to the repolarization phase during action potential firing. The channel forms a homodimer with each subunit possessing its own ion conduction pathway, producing double-barreled currents regulated by two types of gates: fast glutamate gates controlling each subunit independently and a slow common gate operating both subunits simultaneously. CLC1 exhibits significant open probability at resting membrane potential and is further activated upon depolarization. It shows ion selectivity for chloride > thiocyanate > bromide > nitrate > iodide.
Technical Parameters
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Species Human
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Source HEK293
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Tag Tag Free
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Accession
P35523 (K81-L988)
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Gene ID1180
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Protein Length
Partial
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Synonyms
CLCN1; Chloride Channel Protein 1; Chloride Voltage-Gated Channel 1; Chloride Channel, Voltage-Sensitive 1; ClC-1; Chloride Channel 1, Skeletal Muscle; CLC1; Thomsen Disease, Autosomal Dominant; Chloride Channel Protein, Skeletal Muscle; Uncharacterized P
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AA Sequence
KTGSSSTVDSKDEDHYSKCQDCIHRLGQVVRRKLGEDGIFLVLLGLLMALVSWSMDYVSAKSLQAYKWSYAQMQPSLPLQFLVWVTFPLVLILFSALFCHLISPQAVGSGIPEMKTILRGVVLKEYLTMKAFVAKVVALTAGLGSGIPVGKEGPFVHIASICAAVLSKFMSVFCGVYEQPYYYSDILTVGCAVGVGCCFGTPLGGVLFSIEVTSTYFAVRNYWRGFFAATFSAFVFRVLAVWNKDAVTITALFRTNFRMDFPFDLKELPAFAAIGICCGLLGAVFVYLHRQVMLGVRKHKALSQFLAKHRLLYPGIVTFVIASFTFPPGMGQFMAGELMPREAISTLFDNNTWVKHAGDPESLGQSAVWIHPRVNVVIIIFLFFVMKFWMSIVATTMPIPCGGFMPVFVLGAAFGRLVGEIMAMLFPDGILFDDIIYKILPGGYAVIGAAALTGAVSHTVSTAVICFELTGQIAHILPMMVAVILANMVAQSLQPSLYDSIIQVKKLPYLPDLGWNQLSKYTIFVEDIMVRDVKFVSASYTYGELRTLLQTTTVKTLPLVDSKDSMILLGSVERSELQALLQRHLCPERRLRAAQEMARKLSELPYDGKARLAGEGLPGAPPGRPESFAFVDEDEDEDLSGKSELPPSLALHPSTTAPLSPEEPNGPLPGHKQQPEAPEPAGQRPSIFQSLLHCLLGRARPTKKKTTQDSTDLVDNMSPEEIEAWEQEQLSQPVCFDSCCIDQSPFQLVEQTTLHKTHTLFSLLGLHLAYVTSMGKLRGVLALEELQKAIEGHTKSGVQLRPPLASFRNTTSTRKSTGAPPSSAENWNLPEDRPGATGTGDVIAASPETPVPSPSPEPPLSLAPGKVEGELEELELVESPGLEEELADILQGPSLRSTDEEDEDELIL
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Predicted Molecular Mass
100.1 kDa
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Solution.
<1 EU/μg, determined by LAL method.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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