CNPY2 Protein, Human (HEK293, His)
Based on 1 Customer Validation
CNPY2 Protein, a positive regulator of neurite outgrowth, stabilizes the myosin regulatory light chain (MRLC) by preventing MIR-mediated ubiquitination and proteasomal degradation. The interaction with MYLIP/MIR highlights CNPY2's crucial role in facilitating MRLC stability and promoting neurite outgrowth. CNPY2 Protein, Human (HEK293, His) is the recombinant human-derived CNPY2 protein, expressed by HEK293 , with C-His labeled tag.
- Species: Human
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
CNPY2 Protein, a positive regulator of neurite outgrowth, stabilizes the myosin regulatory light chain (MRLC) by preventing MIR-mediated ubiquitination and proteasomal degradation. The interaction with MYLIP/MIR highlights CNPY2's crucial role in facilitating MRLC stability and promoting neurite outgrowth. CNPY2 Protein, Human (HEK293, His) is the recombinant human-derived CNPY2 protein, expressed by HEK293 , with C-His labeled tag.
Background
CNPY2, a positive regulator of neurite outgrowth, exerts its function by stabilizing the myosin regulatory light chain (MRLC). It plays a crucial role in preventing MIR-mediated ubiquitination of MRLC, thereby averting its subsequent proteasomal degradation. The interaction between CNPY2 and MYLIP/MIR underscores its regulatory influence on MRLC stability, emphasizing its significance in facilitating neurite outgrowth.
MCE Validation Data
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Purity - SDS-PAGE
Purity - SDS-PAGE
Technical Parameters
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Species Human
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Source HEK293
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Tag C-6*His
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Accession
Q9Y2B0-1 (R21-S178)
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Molecular Construction
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N-term
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CNPY2 (M1-S178)
Accession # Q9Y2B0 -
His
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C-term
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Protein Length
Full Length of Isoform-1
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Synonyms
CNPY2; MIR-Interacting Saposin-Like Protein; Prev. TMEM4; Protein Canopy Homolog 2; ZSIG9; MSAP; Transmembrane Protein 4; Canopy 2 Homolog (Zebrafish); HP10390; Canopy FGF Signaling Regulator 2; Putative Secreted Protein Zsig9
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AA Sequence
RRSQDLHCGACRALVDELEWEIAQVDPKKTIQMGSFRINPDGSQSVVEVPYARSEAHLTELLEEICDRMKEYGEQIDPSTHRKNYVRVVGRNGESSELDLQGIRIDSDISGTLKFACESIVEEYEDELIEFFSREADNVKDKLCSKRTDLCDHALHIS
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Molecular Weight
Approximately 20 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
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Data Sheet (235 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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