CNTFR alpha Protein, Human (sf9, His)

CNTFR alpha Protein, crucial in protein folding, binds cytosolic chaperonin (c-CPN) and facilitates transfer of target proteins. It aids nascent polypeptide chains' folding amidst diverse pathways. Structurally, PFDN1 forms a heterohexamer with two PFD-alpha and four PFD-beta subunits. Additionally, CNTFR alpha Protein serves as a receptor for the neurotropic cytokine CLCF1/CLC and CRLF1/CLF-1 heterodimer. It interacts with IL6ST/GP130 and IL27RA/WSX1 for humanin binding. Furthermore, it forms a heterotrimer with LIFR and IL6ST, interacting with SORL1 and potentially promoting internalization and lysosomal degradation. CNTFR alpha Protein, Human (sf9, His) is the recombinant human-derived CNTFR alpha protein, expressed by Sf9 insect cells, with C-His labeled tag. The total length of CNTFR alpha Protein, Human (sf9, His) is 324 a.a., with molecular weight of 45-48 KDa.

The CNTFR alpha protein plays a crucial role in protein folding by specifically binding to cytosolic chaperonin (c-CPN) and facilitating the transfer of target proteins to it. It also binds to nascent polypeptide chains, aiding in their folding process within an environment where numerous alternative pathways for nonnative proteins exist. Structurally, the PFDN1 protein forms a heterohexamer consisting of two PFD-alpha type and four PFD-beta type subunits. Additionally, CNTFR alpha protein acts as a receptor for the heterodimeric neurotropic cytokine composed of CLCF1/CLC and CRLF1/CLF-1. It also forms a complex with IL6ST/GP130 and IL27RA/WSX1 to interact with the neuroprotective peptide humanin. Furthermore, it forms a heterotrimer with LIFR and IL6ST and interacts with SORL1, potentially promoting internalization and lysosomal degradation.

Human

Sf9 insect cells

C-His

P26992 (Q23-P346)

1271  [NCBI]

45-48 kDa.

Greater than 95% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.