Cochlin/COCH Protein, Human (HEK293, His)
Based on 1 Customer Validation
Cochlin/COCH protein is involved in regulating cell shape and motility in the trabecular meshwork. It exists as a monomer and may form homodimers. Additionally, Cochlin interacts with type II collagen, SLC44A2, and ANXA2. Cochlin/COCH Protein, Human (HEK293, His) is the recombinant human-derived Cochlin/COCH protein, expressed by HEK293 , with N-His labeled tag.
- Species: Human
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
Cochlin/COCH protein is involved in regulating cell shape and motility in the trabecular meshwork. It exists as a monomer and may form homodimers. Additionally, Cochlin interacts with type II collagen, SLC44A2, and ANXA2. Cochlin/COCH Protein, Human (HEK293, His) is the recombinant human-derived Cochlin/COCH protein, expressed by HEK293 , with N-His labeled tag.
Background
Cochlin (COCH) protein emerges as a key player in orchestrating cell shape and motility within the trabecular meshwork. Existing as a monomer, Cochlin also exhibits the potential to form homodimers. Its interaction with type II collagen highlights its involvement in the extracellular matrix dynamics. Additionally, Cochlin engages in critical interactions with SLC44A2, emphasizing its role in cellular processes. Furthermore, its association with ANXA2 underscores its participation in intricate molecular networks essential for cellular functions.
Technical Parameters
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Species Human
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Source HEK293
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Tag N-10*His
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Accession
O43405 (E25-Q550)
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Molecular Construction
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N-term
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His
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COCH (E25-Q550)
Accession # O43405 -
C-term
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Protein Length
Full Length of Mature Protein
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Synonyms
COCH; Coagulation Factor C Homolog, Cochlin (Limulus Polyphemus); Prev. DFNA9; Coagulation Factor C (Limulus Polyphemus Homolog); Cochlin; Prev. DFNA31; DFNB110; COCH-5B2; Cochlin; COCH5B2
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AA Sequence
EGAAPIAITCFTRGLDIRKEKADVLCPGGCPLEEFSVYGNIVYASVSSICGAAVHRGVISNSGGPVRVYSLPGRENYSSVDANGIQSQMLSRWSASFTVTKGKSSTQEATGQAVSTAHPPTGKRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTVDAGVRKGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVTFVDKAVCRNNGFFSYHMPNWFGTTKYVKPLVQKLCTHEQMMCSKTCYNSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRTEFSFTDYSTKENVLAVIRNIRYMSGGTATGDAISFTVRNVFGPIRESPNKNFLVIVTDGQSYDDVQGPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFFTREFTGLEPIVSDVIRGICRDFLESQQ
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Predicted Molecular Mass
59.4 kDa
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Molecular Weight
Approximately 66 kDa & 48 kDa & 18 kDa, based on SDS-PAGE under reducing conditions.
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Glycosylation
Yes
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4, 5% trehalose, 5% mannitol and 0.01% Tween 80.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
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Data Sheet (238 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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