Complement C1s Protein, Cynomolgus (HEK293, His)
C1s/Complement component C1s, a serine protease and B chain, forms C1 with C1q and C1r, initiating the classical complement pathway. Activated by C1r, C1s then activates downstream components C2 and C4, crucially driving the complement system cascade. Complement C1s Protein, Cynomolgus (HEK293, His) is expressed by HEK293 , with C-His labeled tag.
- Species: Cynomolgus
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
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Biological Activity
Description
C1s/Complement component C1s, a serine protease and B chain, forms C1 with C1q and C1r, initiating the classical complement pathway. Activated by C1r, C1s then activates downstream components C2 and C4, crucially driving the complement system cascade. Complement C1s Protein, Cynomolgus (HEK293, His) is expressed by HEK293 , with C-His labeled tag.
Background
C1s, a serine protease, constitutes the B chain that, in conjunction with C1q and C1r, assembles to create C1, the initial component in the classical pathway of the complement system. Activation of C1s is facilitated by C1r, enabling it to subsequently activate downstream components C2 and C4, thereby initiating the cascade of events essential for complement system function.
Technical Parameters
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Species Cynomolgus
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Source HEK293
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Tag C-His
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Accession
A0A2K5VQX9 (E16-D688)
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Gene ID102137207
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Molecular Construction
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N-term
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Complement C1s (E16-D688)
Accession # A0A2K5VQX9 -
His
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C-term
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Protein Length
Full Length of Mature Protein
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Synonyms
Complement C1s
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AA Sequence
EPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIMSGDTEEGRLCGQRTSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDAPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTVRREDFDVEPADSEGNCLDSLVFVAGDQQFGPYCGRGFPGPLNIETKSNALDIIFQTDLTGQNKGWKLRYHGDPMPCPKEETPTSVWEPAKAKYVFKDVVRITCLDGFEVVEGRVGATSFHSTCQSNGKWSNSKLKCQPVDCGIPESIENGKFEDPESTLFGSVTRYTCEEPYYYMENGGNGQYHCASNGSWVNEALSPELPKCVPVCGVPREPFEGKQRIIGGSDADIKNFPWQVFFDNPWAGGALIDEYWVLTAAHVVEGNQEPTMYVGSTSVQTSRLAKSKMLTSERVFIHPGWKLLEVPEARTNFDNDIALVQLKDPVKMGPTVAPICLPGTSSDYNLMDGDLGLIAGWGRTEKRDRALRLKAAMLPVAPLRKCREVKVENPKADAGAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYVAGLVSWGPQCGTYGLYTRVQNYVDWIKKTMQENSTPSKD
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Predicted Molecular Mass
76.3 kDa
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Molecular Weight
Approximately 92 kDa & 58 kDa & 32 kDa & 26 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
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Purity
≥ 95%, as determined by reducing SDS-PAGE. ≥ 95%, as determined by HPLC.
Product Properties
Lyophilized powder
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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