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CSPG5 Protein, Mouse (HEK293, His)

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CSPG5 protein plays a key role as a growth and differentiation factor in neuritogenesis and may induce ERBB3 activation and participate in signaling pathways related to cell growth and differentiation. Its ability to bind to TNR and possibly TNC suggests interactions with key molecules in cellular processes. CSPG5 Protein, Mouse (HEK293, His) is the recombinant mouse-derived CSPG5 protein, expressed by HEK293 , with C-His labeled tag.

For research use only. We do not sell to patients.
  • Species: Mouse
  • Source: HEK293
  • Storage:
    Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
  • Biological Activity
  • Technical Parameters
  • Product Properties
  • Documentation
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Biological Activity

Description

CSPG5 protein plays a key role as a growth and differentiation factor in neuritogenesis and may induce ERBB3 activation and participate in signaling pathways related to cell growth and differentiation. Its ability to bind to TNR and possibly TNC suggests interactions with key molecules in cellular processes. CSPG5 Protein, Mouse (HEK293, His) is the recombinant mouse-derived CSPG5 protein, expressed by HEK293 , with C-His labeled tag.

Background

The CSPG5 protein appears to play a pivotal role as a growth and differentiation factor in neuritogenesis. Its potential induction of ERBB3 activation underscores its involvement in signaling pathways associated with cellular growth and differentiation. CSPG5 also exhibits binding capabilities with TNR and likely TNC, suggesting its interaction with key molecules in cellular processes. Furthermore, it interacts with ERBB3 and GOPC, indicating a network of associations that may contribute to its functional roles. Notably, CSPG5 interacts with MDK independently of the presence of chondroitin sulfate chains, promoting the elongation of oligodendroglial precursor-like cells. These findings highlight the multifaceted nature of CSPG5's involvement in neurodevelopmental processes, suggesting its significance in orchestrating cellular responses and interactions critical for proper nervous system development.

Technical Parameters

  • Species Mouse
  • Source HEK293
  • Tag C-8*His
  • Accession

    Q71M36-1 (V31-C423)

  • Gene ID
    29873  [NCBI]
  • Molecular Construction
    • N-term
    • CSPG5 (V31-C423)
      Accession # Q71M36-1
    • 8*His
    • C-term
  • Protein Length

    Extracellular Domain

  • Synonyms

    CSPG5; Chondroitin Sulfate Proteoglycan 5 (Neuroglycan C); Chondroitin Sulfate Proteoglycan 5; Neuroglycan C; NGC; CALEB; Acidic Leucine-Rich EGF-Like Domain-Containing Brain Protein

  • AA Sequence

    VPARETGSAIEAEELVRSSLAWESRANDTREEAGLPAAGEDETSWTERGSEMAAVGPGVGPEEALEASAAVTGTAWLEADGPGLGGVTAEAGSGDAQTLPATLQAPDEALGSSTMPPAIPEATETSGPPSPAVHDKPSVGPELPKEIPLEVRLNLGGSTPEPTFPLQGTLETQPASDIIDIDYFEGLDSEGRGADMGSFPGSPGTSENHPDTEGETPSWSLLDLYDDFTPFDESDFYPTTSFYDDLEEEEEEEEDKDTVGGGDLEDENDLLLPSQKPGVGPGTGQPTNRWHAVPPQHTLGMVPGSSISLRPRPGDPGKDLASGENGTECRVGFVRHNGSCRSVCDLFPSYCHNGGQCYLVENIGAFCRCNTQDYIWHKGMRCESIITDFQVMC

  • Predicted Molecular Mass

    42.7 kDa

  • Molecular Weight

    Approximately 60-80 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.

  • Glycosylation

    Yes

  • Purity

    ≥ 95%, as determined by Bis-Tris PAGE.

Product Properties

Appearance

Lyophilized powder.

Formulation

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4, 8% trehalose.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.

Storage & Stability

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Room temperature in continental US; may vary elsewhere.

Calculators

Reconstitution Calculator

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

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Dilution Calculator

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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The Specific Activity Calculator Equation
  • Specific Activity (Unit/mg)
  • Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) Specific Activity (Unit/mg)
Unit/mg
= 106 ÷
Biological Activity (ED50) Biological Activity (ED50)
106 ÷
ng/mL
MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

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