1. Recombinant Proteins
  2. Enzymes & Regulators
  3. Phosphatase
  4. Protein tyrosine phosphatases
  5. Dual Specificity Protein Phosphatase 14 (DUSP14)
  6. DUSP14 Protein, Human (His-MBP)

DUSP14 Protein, Human (His-MBP)

Cat. No.: HY-P76307
Handling Instructions

DUSP14 protein can inactivate MAP kinase and dephosphorylate ERK, JNK and p38 MAP kinase. Its negative regulation extends to TCR signaling, where DUSP14 dephosphorylates the MAP3K7 adapter TAB1, resulting in inactivation. DUSP14 Protein, Human (His-MBP) is the recombinant human-derived DUSP14 protein, expressed by E. coli , with N-His, N-MBP labeled tag. The total length of DUSP14 Protein, Human (His-MBP) is 191 a.a., with molecular weight of ~60 KDa.

For research use only. We do not sell to patients.

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Description

DUSP14 protein can inactivate MAP kinase and dephosphorylate ERK, JNK and p38 MAP kinase. Its negative regulation extends to TCR signaling, where DUSP14 dephosphorylates the MAP3K7 adapter TAB1, resulting in inactivation. DUSP14 Protein, Human (His-MBP) is the recombinant human-derived DUSP14 protein, expressed by E. coli , with N-His, N-MBP labeled tag. The total length of DUSP14 Protein, Human (His-MBP) is 191 a.a., with molecular weight of ~60 KDa.

Background

The DUSP14 Protein assumes a crucial role in the inactivation of MAP kinases, exhibiting dephosphorylation activity towards ERK, JNK, and p38 MAP-kinases. Its negative regulatory function extends to TCR signaling, where DUSP14 dephosphorylates the MAP3K7 adapter TAB1, leading to its inactivation. This mechanism underscores DUSP14's role in modulating the TCR signaling pathway, revealing its involvement in regulating immune responses. The dephosphorylation activity of DUSP14 on key components of MAP kinase cascades highlights its capacity to finely tune cellular signaling, with potential implications for various physiological processes influenced by MAP kinase pathways.

Species

Human

Source

E. coli

Tag

N-His;N-MBP

Accession

O95147 (M1-H191)

Gene ID
Molecular Construction
N-term
His-MBP
DUSP14 (M1-H191)
Accession # O95147
C-term
Synonyms
Dual specificity protein phosphatase 14; MKP-L; MKP-6; DUSP14
Molecular Weight

Approximately 60 kDa.

Purity

Greater than 88% as determined by reducing SDS-PAGE

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Product Name:
DUSP14 Protein, Human (His-MBP)
Cat. No.:
HY-P76307
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