DUSP14 - dual specificity phosphatase 14 Gene

Also Known as MKP6; MKP-L

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 11072

About DUSP14

Cytogenetic location: 17q12 Genomic coordinates (GRCh38): 17:37,488,566-37,513,498 (from NCBI)

This gene has 3 transcripts (splice variants), 1 gene allele, 124 orthologues and 30 paralogues. Broad expression in thyroid (RPKM 9.3), skin (RPKM 8.7) and 24 other tissues.

Summary

Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine Phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP14 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase Phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]

DUSP14 Products (1)

mRNA Protein Name
NM_007026.4 NP_008957.1 dual specificity protein phosphatase 14

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DUSP14 Protein Structure

DSPc

DSPc: Dual specificity phosphatase, catalytic domain (34 - 164)

  • 0
  • 100
  • 198 a.a.
Protein Preferred Names Protein Names

dual specificity protein phosphatase 14

  • MAP kinase phosphatase 6

DUSP14 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
DUSP14 O95147 CBY2 Homo sapiens Q8NA61
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant DUSP14 Proteins

Cat. No. Product Name Accession Purity
HY-P76307 DUSP14 Protein, Human (His) O95147 (M1-H191) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Variola Major

  • Smallpox
Chromosome 17q12 Deletion Syndrome

  • 17q12 Microdeletion Syndrome

  • Del(17)(Q12)

  • Monosomy 17q12
Frontometaphyseal Dysplasia

  • Fmd

  • Dysplasia, Frontometaphyseal
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-112478 PTP Inhibitor IV Inhibitor 99.86% Unkown
HY-RS04055 DUSP14 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17780 Dusp14 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24247 Dusp14 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris DUSP14 VGNC VGNC:40129
Rattus norvegicus DUSP14 RGD RGD:1307415
Macaca mulatta DUSP14 VGNC VGNC:71851
Felis catus DUSP14 VGNC VGNC:61662
Mus musculus DUSP14 MGD MGI:1927168
Bos taurus DUSP14 VGNC VGNC:28252
Others DUSP14 NCBI