ERK3 Protein, Human (Inactive, L290V)
ERK3 Protein, an atypical MAPK, phosphorylates MAP2 and MAPKAPK5. Interacting with MAPKAPK5, ERK3/MAPK6 undergoes Ser-189 phosphorylation, facilitating MAPKAPK5 activation. Activated MAPKAPK5 reciprocally phosphorylates ERK3/MAPK6. The complex's precise functional implications, especially in cell cycle entry, remain elusive. ERK3 Protein, Human (L290V) is the recombinant human-derived ERK3 protein, expressed by E. coli , with tag free.
- Species: Human
- Source: E. coli
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Biological Activity
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Product Properties
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Biological Activity
ERK3 Protein, an atypical MAPK, phosphorylates MAP2 and MAPKAPK5. Interacting with MAPKAPK5, ERK3/MAPK6 undergoes Ser-189 phosphorylation, facilitating MAPKAPK5 activation. Activated MAPKAPK5 reciprocally phosphorylates ERK3/MAPK6. The complex's precise functional implications, especially in cell cycle entry, remain elusive. ERK3 Protein, Human (L290V) is the recombinant human-derived ERK3 protein, expressed by E. coli , with tag free.
ERK3, an atypical MAPK protein, exhibits the capacity to phosphorylate microtubule-associated protein 2 (MAP2) and MAPKAPK5. The intricacies of the complex formed with MAPKAPK5 are still under scrutiny, but a series of phosphorylation events unfolds within this interaction. Upon binding with atypical MAPKAPK5, ERK3/MAPK6 undergoes phosphorylation at Ser-189, subsequently facilitating the phosphorylation and activation of MAPKAPK5. In turn, activated MAPKAPK5 reciprocally phosphorylates ERK3/MAPK6. The precise functional implications of this complex interplay remain elusive, although it may play a role in promoting entry into the cell cycle.
Technical Parameters
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Species Human
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Source E. coli
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Tag Tag Free
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Accession
Q16659 (M9-I327, L290V)
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Gene ID5597
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Molecular Construction
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N-term
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ERK3 (M9-I327, L290V)
Accession # Q16659 -
C-term
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Protein Length
Partial
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Synonyms
MAPK6; Mitogen-activated protein kinase 6; MAP kinase 6; MAPK 6; Extracellular signal-regulated kinase 3; ERK-3; MAP kinase isoform p97; p97-MAPK
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AA Sequence
MNIHGFDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVKHALREIKIIRRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREAVDFLEQILTFSPMDRLTAEEALSHPYMSIYSFPMDEPI
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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