FPRP/PTGFRN Protein, Human (HEK293, His)

FPRP/PTGFRN protein plays a key role in regulating prostaglandin F2-α (PGF2-α) signaling by inhibiting the binding of PGF2-α to its FP receptor. This inhibition reduces receptor number without changing the affinity constant, revealing subtle mechanisms. FPRP/PTGFRN Protein, Human (HEK293, His) is the recombinant human-derived FPRP/PTGFRN protein, expressed by HEK293 , with C-His labeled tag. The total length of FPRP/PTGFRN Protein, Human (HEK293, His) is 807 a.a., with molecular weight of 100-110 kDa.

FPRP/PTGFRN protein plays a pivotal role in the regulation of prostaglandin F2-alpha (PGF2-alpha) signaling by inhibiting the binding of PGF2-alpha to its specific FP receptor. Notably, this inhibition occurs through a reduction in receptor number rather than an alteration in the affinity constant, indicating a nuanced mechanism of action. Functionally coupled with the PGF2-alpha receptor, FPRP/PTGFRN is implicated in myoblasts where it associates with tetraspanins CD9 and CD81, effectively preventing myotube fusion during muscle regeneration. The protein forms complexes with CD9, CD81, and IGSF8, emphasizing its involvement in intricate cellular interactions. Furthermore, interactions with additional tetraspanins such as CD63, CD82, and CD151 underscore the multifaceted nature of FPRP/PTGFRN in modulating cellular processes.

Human

HEK293

C-His

Q9P2B2 (V26–P832)

5738  [NCBI]

100-110 kDa

Greater than 95% as determined by Tris-Bis PAGE.

<1 EU/μg, determined by LAL method.