Galectin-1/LGALS1 Protein, Human (HEK293, hFc)
Galectin-1/LGALS1 is a lectin that binds β-galactoside and complex carbohydrates and regulates apoptosis, proliferation, and differentiation. It inhibits CD45 phosphatase activity, blocks Lyn kinase dephosphorylation, and induces T cell apoptosis. Galectin-1/LGALS1 Protein, Human (HEK293, hFc) is the recombinant human-derived Galectin-1/LGALS1 protein, expressed by HEK293, with N-hFc labeled tag.
- Species: Human
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Galectin-1/LGALS1 is a lectin that binds β-galactoside and complex carbohydrates and regulates apoptosis, proliferation, and differentiation. It inhibits CD45 phosphatase activity, blocks Lyn kinase dephosphorylation, and induces T cell apoptosis. Galectin-1/LGALS1 Protein, Human (HEK293, hFc) is the recombinant human-derived Galectin-1/LGALS1 protein, expressed by HEK293, with N-hFc labeled tag.
The Galectin-1/LGALS1 protein serves as a lectin with the ability to bind beta-galactoside and a diverse range of complex carbohydrates. It plays a pivotal role in the regulation of apoptosis, cell proliferation, and cell differentiation. Galectin-1/LGALS1 exerts its influence by inhibiting the protein phosphatase activity of CD45, consequently impeding the dephosphorylation of Lyn kinase. Additionally, it acts as a potent inducer of T-cell apoptosis. Existing as a homodimer, Galectin-1/LGALS1 forms interactions with a variety of cellular entities, including CD2, CD3, CD4, CD6, CD7, CD43, ALCAM, and CD45. It also binds LGALS3BP, laminin (via poly-N-acetyllactosamine), and SUSD2. Notably, Galectin-1/LGALS1 engages in an interaction with the cargo receptor TMED10, facilitating translocation from the cytoplasm into the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) and subsequent secretion.
Technical Parameters
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Species Human
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Source HEK293
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Tag N-hFc
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Accession
P09382 (A2-D135)
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Gene ID3956
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Protein Length
Full Length of Mature Protein
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Synonyms
LGALS1; Galaptin; Galectin 1; HLBP14; Lectin, Galactoside-Binding, Soluble, 1; Gal-1; GBP; HBL; Beta-Galactoside-Binding Lectin L-14-I; HPL; Putative MAPK-Activating Protein PM12; Epididymis Secretory Sperm Binding Protein; 14 KDa Laminin-Binding Protein;
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AA Sequence
ACGLVASNLNLKPGECLRVRGEVAPDAKSFVLNLGKDSNNLCLHFNPRFNAHGDANTIVCNSKDGGAWGTEQREAVFPFQPGSVAEVCITFDQANLTVKLPDGYEFKFPNRLNLEAINYMAADGDFKIKCVAFD
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Predicted Molecular Mass
41.9 kDa
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Molecular Weight
Approximately 48-55 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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