Galectin-8/LGALS8 Protein, Rat (GST)
Galectin-8 belongs to the family of animal lectins that bind to different glycoconjugates. Galectin-8 inhibits MTOR and AMPK signaling pathways to induce autophagy in response to lysosomal damage. Galectin-8 is highly expressed in a variety of tumors. Galectin-8/LGALS8 Protein, Rat (GST) is the recombinant rat-derived Galectin-8 protein, expressed by E. coli , with N-GST labeled tag.
- Species: Rat
- Source: E. coli
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
Galectin-8 belongs to the family of animal lectins that bind to different glycoconjugates. Galectin-8 inhibits MTOR and AMPK signaling pathways to induce autophagy in response to lysosomal damage. Galectin-8 is highly expressed in a variety of tumors. Galectin-8/LGALS8 Protein, Rat (GST) is the recombinant rat-derived Galectin-8 protein, expressed by E. coli , with N-GST labeled tag.
Galectin-8 belongs to the family of animal lectins that bind to different glycoconjugates. As a secreted protein, Galectin-8 is found in body fluids or the serum of patients with breast cancer and those with colon cancer. Extracellular Galectin-8 promotes cell adhesion by binding to cell adhesion molecules such as integrins CD44, CD166 and Podoplanin. Galectin-8 performs its intracellular function by marking the vacuoles invaded by pathogens to be destroyed by autophagy. Galectin-8 inhibited MTOR and AMPK in response to lysosomal injury induced autophagy in membrane disturbances. Galectin-8 is highly expressed in a variety of tumors[1][2][3].
Technical Parameters
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Species Rat
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Source E. coli
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Tag N-GST
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Accession
Q6IN24 (M1-W316)
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Molecular Construction
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N-term
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GST
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Galectin-8/LGALS8 (M1-W316)
Accession # Q6IN24 -
C-term
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Protein Length
Full Length
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Synonyms
LGALS8; Galectin-8; Galectin 8; Po66-CBP; PCTA-1; Gal-8; Lectin, Galactoside-Binding, Soluble, 8; Po66 Carbohydrate Binding Protein; Prostate Carcinoma Tumor Antigen 1; Alternative Protein LGALS8; Po66 Carbohydrate-Binding Protein; Galectin; Galectin-8g;
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AA Sequence
MLSLSNLQNIIYNPTIPYVSTITEQLKPGSLIVIRGHVPKDSERFQVDFQHGNSLKPRADVAFHFNPRFKRSNCIVCNTLTNEKWGWEEITHDMPFRKEKSFEIVIMVLKNKFQVAVNGKHILLYAHRINPEKIDTLGIYGKVNIHSIGFRFSSDLQSMETSTLGLTQISKENIQKSGKLHLSLPFEARLNASMGPGRTVVVKGEVNTNAKSFNVDLVAGRSRDIALHLNPRLNVKAFVRNSFLQDAWGEEERNITCFPFSSGMYFEMIIYCDVREFKVAVNGVHSLEYKHRFKDLSSIDTLAVDGDIRLLDVRSW
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Predicted Molecular Mass
63.2 kDa
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Molecular Weight
Approximately 55kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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