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  4. GAT1 Protein, Human (HEK293)

GAT1 Protein, Human (HEK293) is the recombinant human-derived GAT1, expressed by HEK293 , with tag Free labeled tag.

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Description

GAT1 Protein, Human (HEK293) is the recombinant human-derived GAT1, expressed by HEK293 , with tag Free labeled tag.
Background

GAT1 mediates the transport of gamma-aminobutyric acid (GABA) along with sodium and chloride ions, primarily responsible for GABA reuptake from the synaptic cleft (PubMed:30132828). However, GABA translocation may also occur in the reverse direction, leading to GABA release (By similarity). The direction and magnitude of GABA transport depend on thermodynamic conditions, influenced by membrane potential and intracellular/extracellular concentrations of Na(+), Cl(-), and GABA (By similarity). Additionally, GAT1 can facilitate sodium- and chloride-dependent hypotaurine transport, though with significantly lower efficiency compared to GABA (By similarity).
Species

Human
Source

HEK293
Tag

Tag Free
Accession

P30531 (M1-I599)
Gene ID

6529
Protein Length

Full Length
Synonyms
GABATR; GABT1; GAT1
AA Sequence

MATNGSKVADGQISTEVSEAPVANDKPKTLVVKVQKKAADLPDRDTWKGRFDFLMSCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVWKLAPMFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFTTTLPWKQCDNPWNTDRCFSNYSMVNTTNMTSAVVEFWERNMHQMTDGLDKPGQIRWPLAITLAIAWILVYFCIWKGVGWTGKVVYFSATYPYIMLIILFFRGVTLPGAKEGILFYITPNFRKLSDSEVWLDAATQIFFSYGLGLGSLIALGSYNSFHNNVYRDSIIVCCINSCTSMFAGFVIFSIVGFMAHVTKRSIADVAASGPGLAFLAYPEAVTQLPISPLWAILFFSMLLMLGIDSQFCTVEGFITALVDEYPRLLRNRRELFIAAVCIISYLIGLSNITQGGIYVFKLFDYYSASGMSLLFLVFFECVSISWFYGVNRFYDNIQEMVGSRPCIWWKLCWSFFTPIIVAGVFIFSAVQMTPLTMGNYVFPKWGQGVGWLMALSSMVLIPGYMAYMFLTLKGSLKQRIQVMVQPSEDIVRPENGPEQPQAGSSTSKEAYI

Predicted Molecular Mass
67.8 kDa
Glycosylation
Yes
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Instruction de manipulation (2659 KB)

GAT1 Protein, Human (HEK293) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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