GAT1 Protein, Human (HEK293)
GAT1 Protein, Human (HEK293) is the recombinant human-derived GAT1, expressed by HEK293 , with tag Free labeled tag.
- Species: Human
- Source: HEK293
-
Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Technical Parameters
-
Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
GAT1 Protein, Human (HEK293) is the recombinant human-derived GAT1, expressed by HEK293 , with tag Free labeled tag.
Background
GAT1 mediates the transport of gamma-aminobutyric acid (GABA) along with sodium and chloride ions, primarily responsible for GABA reuptake from the synaptic cleft (PubMed:30132828). However, GABA translocation may also occur in the reverse direction, leading to GABA release (By similarity). The direction and magnitude of GABA transport depend on thermodynamic conditions, influenced by membrane potential and intracellular/extracellular concentrations of Na(+), Cl(-), and GABA (By similarity). Additionally, GAT1 can facilitate sodium- and chloride-dependent hypotaurine transport, though with significantly lower efficiency compared to GABA (By similarity).
Technical Parameters
-
Species Human
-
Source HEK293
-
Tag Tag Free
-
Accession
P30531 (M1-I599)
-
Gene ID6529
-
Protein Length
Full Length
-
Synonyms
SLC6A1; Solute Carrier Family 6 (Neurotransmitter Transporter, GABA), Member 1; Solute Carrier Family 6 Member 1; Solute Carrier Family 6 (Neurotransmitter Transporter), Member 1; GABATR; GABA Transporter 1; GAT1; CDNA FLJ57116, Highly Similar To Sodium-
-
AA Sequence
MATNGSKVADGQISTEVSEAPVANDKPKTLVVKVQKKAADLPDRDTWKGRFDFLMSCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVWKLAPMFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFTTTLPWKQCDNPWNTDRCFSNYSMVNTTNMTSAVVEFWERNMHQMTDGLDKPGQIRWPLAITLAIAWILVYFCIWKGVGWTGKVVYFSATYPYIMLIILFFRGVTLPGAKEGILFYITPNFRKLSDSEVWLDAATQIFFSYGLGLGSLIALGSYNSFHNNVYRDSIIVCCINSCTSMFAGFVIFSIVGFMAHVTKRSIADVAASGPGLAFLAYPEAVTQLPISPLWAILFFSMLLMLGIDSQFCTVEGFITALVDEYPRLLRNRRELFIAAVCIISYLIGLSNITQGGIYVFKLFDYYSASGMSLLFLVFFECVSISWFYGVNRFYDNIQEMVGSRPCIWWKLCWSFFTPIIVAGVFIFSAVQMTPLTMGNYVFPKWGQGVGWLMALSSMVLIPGYMAYMFLTLKGSLKQRIQVMVQPSEDIVRPENGPEQPQAGSSTSKEAYI
-
Predicted Molecular Mass
67.8 kDa
-
Glycosylation
Yes
Product Properties
Solution.
<1 EU/μg, determined by LAL method.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz
