glycoprotein/G Protein, HRSV (His)
Glycoproteins/G proteins play a key role in infection by attaching viral particles to the host cell membrane through heparan sulfate interactions, thereby initiating infection. It also interacts with host CX3CR1, the receptor for the CX3C chemokine fractalkine, contributing to immune regulation and promoting infection. glycoprotein/G Protein, HRSV (His) is the recombinant virus-derived glycoprotein/G protein, expressed by E. coli, with N-His labeled tag.
- Species: Virus
- Source: E. coli
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
Glycoproteins/G proteins play a key role in infection by attaching viral particles to the host cell membrane through heparan sulfate interactions, thereby initiating infection. It also interacts with host CX3CR1, the receptor for the CX3C chemokine fractalkine, contributing to immune regulation and promoting infection. glycoprotein/G Protein, HRSV (His) is the recombinant virus-derived glycoprotein/G protein, expressed by E. coli, with N-His labeled tag.
Background
The glycoprotein/G protein plays a pivotal role in infection by attaching the virion to the host cell membrane through interaction with heparan sulfate, initiating the infection. Additionally, it interacts with host CX3CR1, the receptor for the CX3C chemokine fractalkine, contributing to immune modulation and facilitating infection. Distinguished from other paramyxovirus attachment proteins, the glycoprotein lacks both neuraminidase and hemagglutinating activities. Its unique features enable the virus to evade antibody-dependent restriction of replication by functioning as an antigen decoy and modulating the activity of leukocytes carrying Fc-gamma receptors.
Technical Parameters
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Species Virus
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Source E. coli
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Tag N-His
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Accession
O36633-1 (H67-A299)
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Gene ID1489824
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Molecular Construction
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N-term
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His
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HRSV G (H67-A299)
Accession # O36633-1 -
C-term
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Protein Length
Full Length of Mature secreted glycoprotein G Chain
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Synonyms
Major surface glycoprotein G; Attachment glycoprotein G; Membrane-bound glycoprotein; mG; Mature secreted glycoprotein G; Mature secreted glycoprotein G; Mature secreted glycoprotein G; G
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AA Sequence
HKVTLTTVTVQTIKNHTEKNITTYLTQVPPERVSSSKQPTTTSPIHTNSATTSPNTKSETHHTTAQTKGRTTTSTQTNKPSTKPRLKNPPKKPKDDYHFEVFNFVPCSICGNNQLCKSICKTIPSNKPKKKPTIKPTNKPTTKTTNKRDPKTPAKTTKKETTTNPTKKPTLTTTERDTSTSQSTVLDTTTLEHTIQQQSLHSTTPENTPNSTQTPTASEPSTSNSTQNTQSHA
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Predicted Molecular Mass
27.6 kDa
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Molecular Weight
Approximately 33-35 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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