GPD1L Protein, Human (GST)
GPD1L protein regulates cardiac sodium current, with decreased enzymatic activity leading to elevated glycerol 3-phosphate levels.This activates the GPD1L-dependent SCN5A phosphorylation pathway, potentially resulting in reduced sodium current.Altered NAD(H) balance induced by GPD1L may also contribute to the decrease in cardiac sodium current.GPD1L Protein, Human (GST) is the recombinant human-derived GPD1L protein, expressed by E.coli , with N-GST labeled tag.
- Species: Human
- Source: E. coli
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
Description
GPD1L protein regulates cardiac sodium current, with decreased enzymatic activity leading to elevated glycerol 3-phosphate levels.This activates the GPD1L-dependent SCN5A phosphorylation pathway, potentially resulting in reduced sodium current.Altered NAD(H) balance induced by GPD1L may also contribute to the decrease in cardiac sodium current.GPD1L Protein, Human (GST) is the recombinant human-derived GPD1L protein, expressed by E.coli , with N-GST labeled tag.
Background
GPD1L protein is involved in the regulation of cardiac sodium current. A decrease in its enzymatic activity results in elevated glycerol 3-phosphate levels, activating the DPD1L-dependent SCN5A phosphorylation pathway, potentially leading to a reduction in sodium current. Additionally, changes in NAD(H) balance induced by GPD1L may contribute to the decrease in cardiac sodium current.
Technical Parameters
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Species Human
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Source E. coli
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Tag N-GST
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Accession
Q8N335 (M1-T351)
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Molecular Construction
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N-term
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GST
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GPD1L (M1-T351)
Accession # Q8N335 -
C-term
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Protein Length
Full Length
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Synonyms
GPD1L; Glycerol-3-Phosphate Dehydrogenase 1-Like Protein; Glycerol-3-Phosphate Dehydrogenase 1 Like; GPD1-L; KIAA0089; Glycerol-3-Phosphate Dehydrogenase [NAD(+)]
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AA Sequence
MAAAPLKVCIVGSGNWGSAVAKIIGNNVKKLQKFASTVKMWVFEETVNGRKLTDIINNDHENVKYLPGHKLPENVVAMSNLSEAVQDADLLVFVIPHQFIHRICDEITGRVPKKALGITLIKGIDEGPEGLKLISDIIREKMGIDISVLMGANIANEVAAEKFCETTIGSKVMENGLLFKELLQTPNFRITVVDDADTVELCGALKNIVAVGAGFCDGLRCGDNTKAAVIRLGLMEMIAFARIFCKGQVSTATFLESCGVADLITTCYGGRNRRVAEAFARTGKTIEELEKEMLNGQKLQGPQTSAEVYRILKQKGLLDKFPLFTAVYQICYESRPVQEMLSCLQSHPEHT
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Predicted Molecular Mass
65.4 kDa
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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