GRM2 Protein, Human (sf9, His)
GRM2 Protein, Human (sf9, His) is the recombinant human-derived GRM2, expressed by sf9 insect cells , with His labeled tag.
- Species: Human
- Source: Sf9 insect cells
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
GRM2 Protein, Human (sf9, His) is the recombinant human-derived GRM2, expressed by sf9 insect cells , with His labeled tag.
GRM2 is a dimeric G protein-coupled receptor activated by the excitatory neurotransmitter L-glutamate. It plays critical roles in modulating synaptic transmission and neuronal excitability. Upon glutamate activation, GRM2 inhibits presynaptic calcium channels, reducing further glutamate release and dampening excitatory signaling (by similar). Mechanistically, ligand binding induces a conformational change that triggers G protein-mediated signaling and modulates downstream effectors such as adenylate cyclase. Additionally, GRM2 may mediate neurotransmission suppression or participate in synaptogenesis and synaptic stabilization. In microbial infections, GRM2 facilitates influenza virus internalization and serves as a host entry factor for rabies virus and SARS-CoV-2, which hijack its endocytosis pathway for cellular entry.
Technical Parameters
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Species Human
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Source Sf9 insect cells
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Tag His
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Accession
Q14416 (E19-G493)
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Gene ID2912
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Protein Length
Partial
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Synonyms
GRM2; Glutamate Receptor, Metabotropic 2; Glutamate Metabotropic Receptor 2; Metabotropic Glutamate Receptor 2; GPRC1B; Glutamate Receptor Homolog; MGLUR2; MGluR2; MGlu2; GLUR2
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AA Sequence
EGPAKKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHICPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQRLNASFTWVASDGWGALESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTLDTSLIPWASPSAG
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Predicted Molecular Mass
54.7 kDa
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Glycosylation
Yes
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Solution.
<1 EU/μg, determined by LAL method.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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