HAMP protein, Larimichthys crocea
Based on 1 Customer Validation
HAMP protein is a key signaling molecule for iron homeostasis and cooperates with HFE to regulate intestinal iron absorption and macrophage iron storage. HAMP has significant antibacterial effects and shows strong antibacterial activity against Gram-negative bacteria such as Vibrio alginolyticus and Gram-positive bacteria such as Staphylococcus aureus. HAMP protein, Larimichthys crocea is the recombinant HAMP protein, expressed by E. coli , with tag free.
- Species: Others
- Source: E. coli
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
HAMP protein is a key signaling molecule for iron homeostasis and cooperates with HFE to regulate intestinal iron absorption and macrophage iron storage. HAMP has significant antibacterial effects and shows strong antibacterial activity against Gram-negative bacteria such as Vibrio alginolyticus and Gram-positive bacteria such as Staphylococcus aureus. HAMP protein, Larimichthys crocea is the recombinant HAMP protein, expressed by E. coli , with tag free.
HAMP protein appears to function as a signaling molecule crucial for maintaining iron homeostasis, working in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages. Its antimicrobial properties are notable, demonstrating robust antibacterial activity against various Gram-negative bacteria, including V.alginolyticus, V.fluvialis, V.harveyis, and V.parahaemolyticus, with varying minimum inhibitory concentrations (MICs). Additionally, HAMP displays antibacterial activity against Gram-positive bacteria such as B.cereus, B.subtilis, C.glutamicum, M.luteus, M.lysodeikticus, S.aureus, and S.epidermis. Furthermore, it exhibits antifungal activity against A.niger, F.graminearum, and F.solani, while lacking antifungal effects against the yeasts P.pastoris GS115 and C.albicans. These diverse activities underscore the multifaceted role of HAMP in host defense mechanisms against microbial challenges.
Technical Parameters
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Species Others
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Source E. coli
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Tag Tag Free
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Accession
A1Z0M0 (R65-F85)
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Gene ID104926498 [NCBI]
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Molecular Construction
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N-term
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HAMP (R65-F85)
Accession # A1Z0M0 -
C-term
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Protein Length
Full Length of Mature Protein
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Synonyms
HAMP; Liver-Expressed Antimicrobial Peptide 1; Hepcidin Antimicrobial Peptide; Putative Liver Tumor Regressor; LEAP1; Hepcidin; HEPC; PLTR; LEAP-1; Hepcidin Preproprotein; HFE2B
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AA Sequence
RCRFCCRCCPRMRGCGICCRF
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Predicted Molecular Mass
2.5 kDa
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
Lyophilized from a 0.22 μm filtered solution of PBS, 6% trehalose, pH 7.4.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US;may vary elsewhere.
Documentation
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Data Sheet (234 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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