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Hemopexin Protein, Rat (HEK293, His)

Cat. No.: HY-P74901
COA Handling Instructions

Hemopexin Protein, with its heme-binding ability, acts as a transporter, facilitating heme transport to the liver. In the liver, heme is broken down, and the recovered iron is utilized. The liberated hemopexin protein then returns to circulation, underscoring its vital role in efficiently managing heme and iron metabolism in the body. Hemopexin Protein, Rat (HEK293, His) is the recombinant rat-derived Hemopexin protein, expressed by HEK293, with C-His labeled tag. The total length of Hemopexin Protein, Rat (HEK293, His) is 460 a.a., with molecular weight of ~50.4 kDa.

For research use only. We do not sell to patients.

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  • Biological Activity

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Description

Hemopexin Protein, with its heme-binding ability, acts as a transporter, facilitating heme transport to the liver. In the liver, heme is broken down, and the recovered iron is utilized. The liberated hemopexin protein then returns to circulation, underscoring its vital role in efficiently managing heme and iron metabolism in the body. Hemopexin Protein, Rat (HEK293, His) is the recombinant rat-derived Hemopexin protein, expressed by HEK293, with C-His labeled tag. The total length of Hemopexin Protein, Rat (HEK293, His) is 460 a.a., with molecular weight of ~50.4 kDa.

Background

The Hemopexin protein exhibits the ability to bind to heme, serving as a transporter to facilitate its transportation to the liver. Once in the liver, heme is broken down, and the iron is recovered. Subsequently, the hemopexin protein, now free from heme, returns to circulation. This mechanism highlights the crucial role of hemopexin in the efficient management of heme and iron metabolism within the body.

Species

Rat

Source

HEK293

Tag

C-His

Accession

P20059 (M1-Q460)

Gene ID

58917  [NCBI]

Molecular Construction
N-term
Hemopexin (M1-Q460)
Accession # P20059
His
C-term
Synonyms
Hemopexin; Hpx; Hpxn
Molecular Weight

Approximately 50.4 kDa

Purity

Greater than 90% as determined by reducing SDS-PAGE

Appearance

Lyophilized powder

Formulation

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.

Storage & Stability

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Room temperature in continental US; may vary elsewhere.

Documentation

Hemopexin Protein, Rat (HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Reconstitution Calculator

  • Dilution Calculator

  • Specific Activity Calculator

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Hemopexin Protein, Rat (HEK293, His)
Cat. No.:
HY-P74901
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