hERG Protein, Human (HEK293)
The hERG protein is the α subunit of voltage-gated potassium channels and is critical for mediating cardiac delayed rectifier potassium current (IKr). It lacks individual channel activity but dynamically affects properties by forming heterotetramers with other isoforms. hERG Protein, Human (HEK293) is the recombinant human-derived hERG protein, expressed by HEK293, with tag free.
- Species: Human
- Source: HEK293
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
Description
The hERG protein is the α subunit of voltage-gated potassium channels and is critical for mediating cardiac delayed rectifier potassium current (IKr). It lacks individual channel activity but dynamically affects properties by forming heterotetramers with other isoforms. hERG Protein, Human (HEK293) is the recombinant human-derived hERG protein, expressed by HEK293, with tag free.
Background
hERG, the pore-forming α subunit of the voltage-gated inwardly rectifying potassium channel, plays a pivotal role in mediating the rapidly activating component of the delayed rectifying potassium current in the heart (IKr). While it lacks channel activity on its own, hERG dynamically influences channel properties through the formation of heterotetramers with other isoforms. This subunit assembly not only modulates the channel characteristics but also leads to the intracellular retention of the heterotetramers, subsequently undergoing ubiquitin-dependent degradation. The intricate interplay of hERG with other isoforms highlights its regulatory function in the finely tuned orchestration of potassium currents crucial for cardiac physiology.
Technical Parameters
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Species Human
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Source HEK293
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Tag Tag Free
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Accession
Q12809-1 (M1-S1159, ΔP141-A350, ΔS871-R1005)
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Gene ID3757
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Protein Length
Partial
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Synonyms
KCNH2; HERG1; Prev. LQT2; Potassium Voltage-Gated Channel Subfamily H Eag-Related Member 2; HERG; Ether-A-Go-Go-Related Potassium Channel Protein; Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2; Voltage-Gated Channel Subfamily H Member 2; Voltage-Gated Inwardly Rectifying Potassium Channel KCNH2; Human Ether-A-Go-Go-Related Gene; Ether-A-Go-Go-Related Gene Potassium Channel 1; Uncharacterized Protein KCNH2; Voltage-Gated Potassium Channel Subunit Kv11.1; Human Ether-A-Go-Go-Related; Kv11.1; Potassium Channel HERG1; Erg1; Potassium Channel HERG; Ether-A-Go-Go-Related Protein 1; KCNH2 Protein; Long QT Syndrome Type 2; HERG-1; Eag-Related Protein 1; SQT1; Eag Homolog; ERG1; ERG-1; ERG; H-ERG; Potassium Voltage-Gated Channel Subfamily H Member 2; Potassium Channel, Voltage Gated Eag Related Subfamily H, Member 2
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Predicted Molecular Mass
91.6 kDa
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Glycosylation
Yes
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Purity
≥ 80%, as determined by reducing SDS-PAGE.
Product Properties
Solution.
<1 EU/μg, determined by LAL method.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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