HSP10/EPF Protein, Goat/Human/Mouse (His-Avi)
The HSP10/EPF protein in collaboration with Hsp60 promotes the correct folding of the input protein and, under stressful conditions in the mitochondrial matrix, prevents misfolding while promoting the refolding and correct assembly of the unfolded polypeptide. The increased expression of HSP10 protein can inhibit the apoptosis of astrocytoma cells and is associated with poor prognosis. HSP10/EPF Protein, Goat/Human/Mouse (His-Avi) is the recombinant human, mouse-derived HSP10/EPF protein, expressed by E. coli , with C-Avi, N-His labeled tag.
- Species: Human; Mouse
- Source: E. coli
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- References
- Help & FAQs
Biological Activity
The HSP10/EPF protein in collaboration with Hsp60 promotes the correct folding of the input protein and, under stressful conditions in the mitochondrial matrix, prevents misfolding while promoting the refolding and correct assembly of the unfolded polypeptide. The increased expression of HSP10 protein can inhibit the apoptosis of astrocytoma cells and is associated with poor prognosis. HSP10/EPF Protein, Goat/Human/Mouse (His-Avi) is the recombinant human, mouse-derived HSP10/EPF protein, expressed by E. coli , with C-Avi, N-His labeled tag.
Heat shock 10 kDa protein 1 (Hsp10), also known as chaperone protein 10 or Early pregnancy factor (EPF), is a protein encoded by the human HSPE1 gene. The homolog in E. coli is GroES, which is a chaperone protein that usually works in conjunction with GroEL. The HSP10/EPF protein in collaboration with Hsp60 promotes the correct folding of the input protein and, under stressful conditions in the mitochondrial matrix, prevents misfolding while promoting the refolding and correct assembly of the unfolded polypeptide. The increased expression of HSP10 protein can inhibit the apoptosis of astrocytoma cells and is associated with poor prognosis[1][2][3].
Technical Parameters
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Species Human; Mouse
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Source E. coli
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Tag N-Avi;N-8*His
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Accession
A0A8C2NRB8/XP_005676362 (A2-D102)
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Gene ID102173048 [NCBI]
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Protein Length
Full Length of Mature Protein
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Synonyms
HSPE1; Heat Shock 10kD Protein 1 (Chaperonin 10); Heat Shock Protein Family E (Hsp10) Member 1; Heat Shock Protein Family E Member 1; Chaperonin 10; Heat Shock 10kDa Protein 1; CPN10; Early-Pregnancy Factor; EPF; Heat Shock 10kDa Protein 1 (Chaperonin 10)
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AA Sequence
AGQAFRKFLPLFDRVLVERSAAETVTKGGIMLPEKSQGKVLQATVVAVGSGSKGKGGEIQPVSVKVGDKVLLPEYGGTKVVLDDKDYFLFRDGDILGKYVD
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Predicted Molecular Mass
13.7 kDa
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Molecular Weight
Approximately 14 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
References
[1]. David S, et al. Hsp10: anatomic distribution, functions, and involvement in human disease. Front Biosci (Elite Ed). 2013 Jan 1;5(2):768-78. [Content Brief]
[2]. Fucarino A, et al. Role of HSP60/HSP10 in Lung Cancer: Simple Biomarkers or Leading Actors? J Oncol. 2020 Mar 30;2020:4701868. [Content Brief]
[3]. Fan W, et al. Elevated expression of HSP10 protein inhibits apoptosis and associates with poor prognosis of astrocytoma. PLoS One. 2017 Oct 13;12(10):e0185563. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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