IGFBP-3 Protein, Cynomolgus (HEK293, His)
IGFBP-3 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived IGFBP-3 protein, expressed by HEK293, with N-His tag.
- Species: Cynomolgus
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
IGFBP-3 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived IGFBP-3 protein, expressed by HEK293, with N-His tag.
Background
IGFBP-3 Protein, a member of the insulin-like growth factor-binding proteins (IGFBPs), plays a crucial role in extending the half-life of insulin-like growth factors (IGFs) and modulating their growth-promoting effects on cell culture. With the capacity to either inhibit or stimulate IGF-induced cellular responses, IGFBP-3 exerts its regulatory influence by altering the interaction dynamics between IGFs and their respective cell surface receptors. Additionally, IGFBP-3 exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R. Furthermore, IGFBP-3 inhibits the positive effect of humanin on insulin sensitivity and promotes testicular germ cell apoptosis. Interactions with XLKD1 and the formation of a ternary complex with IGF1 or IGF2 and a glycoprotein (ALS) further underscore the diverse roles of IGFBP-3. The intricate network of interactions, including those with humanin and TMEM219, highlights the multifaceted nature of IGFBP-3 in modulating cellular processes and signaling pathways associated with growth and apoptosis.
Technical Parameters
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Species Cynomolgus
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Source HEK293
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Tag N-His
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Accession
XP_005549698.1 (G28-K291)
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Gene ID/
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Protein Length
Partial
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Synonyms
IGFBP3; Binding Protein 53; Insulin Like Growth Factor Binding Protein 3; Binding Protein 29; IBP3; IGFBP-3; Insulin-Like Growth Factor-Binding Protein 3; IBP-3; IGF-Binding Protein 3; CDNA FLJ43234 Fis, Clone HCHON2002964, Highly Similar To Insulin-Like
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AA Sequence
GASSAGLGPVVRCEPCDARALAQCAPPPAVCAELVREPGCGCCLTCALSEGQPCGIYTERCGSGLRCQPSPDEARPLQALLDGRGLCVNSSAVSSLRAYLLPAPPAPGNASESEEDRSAGSVESPSVSSTHRVSDPKFHPVHSKIIIIKKGHAKDSQRYKVDYESQSTDTQNFSSESKRETEYGPCRREMEDTLNHLKFLNVLSPRGVHIPNCDKKGFYKKKQCRPSKGRKRGFCWCVDKYGQPLPGYTTKGKEDVHCYSMQSK
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Predicted Molecular Mass
31.1 kDa
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Molecular Weight
Approximately 41-44 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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