KBTBD6 Protein, Human (Sf9)

KBTBD6 is a key member of the CUL3(KBTBD6/7) E3 ubiquitin ligase complex, acting as a substrate adapter to coordinate the “Lys-48” ubiquitination and subsequent proteasomal degradation of the RAC1 guanine exchange factor TIAM1. This regulatory role enables KBTBD6 to control RAC1 signaling, affecting important processes such as cytoskeletal organization, cell migration, and cell proliferation. KBTBD6 Protein, Human (Sf9) is the recombinant human-derived KBTBD6 protein, expressed by Sf9 insect cells , with tag free. The total length of KBTBD6 Protein, Human (Sf9) is 673 a.a., .

KBTBD6, as a crucial component of the CUL3(KBTBD6/7) E3 ubiquitin ligase complex, functions as a substrate adapter responsible for mediating the 'Lys-48' ubiquitination and subsequent proteasomal degradation of the RAC1 guanine exchange factor (GEF) TIAM1. Through this regulatory mechanism, KBTBD6 governs RAC1 signal transduction, exerting control over diverse downstream biological processes such as cytoskeletal organization, cell migration, and cell proliferation. The ubiquitination process of TIAM1 is contingent on the presence of the membrane-associated protein GABARAP, suggesting a potential local restriction of complex activity. Overall, KBTBD6's involvement in protein ubiquitination highlights its role in modulating cellular signaling pathways.

Human

Sf9 insect cells

Tag Free

Q86V97 (Q2-Q674)

89890

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.