KBTBD8 Protein, Human (sf9)
KBTBD8 in the BCR E3 ubiquitin ligase complex plays a critical regulatory role in neural crest specification. The BCR(KBTBD8) complex coordinates this action by monoubiquitinating NOLC1 and TCOF1. KBTBD8 Protein, Human (sf9) is the recombinant human-derived KBTBD8 protein, expressed by sf9 insect cells , with tag free.
- Species: Human
- Source: Sf9 insect cells
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
KBTBD8 in the BCR E3 ubiquitin ligase complex plays a critical regulatory role in neural crest specification. The BCR(KBTBD8) complex coordinates this action by monoubiquitinating NOLC1 and TCOF1. KBTBD8 Protein, Human (sf9) is the recombinant human-derived KBTBD8 protein, expressed by sf9 insect cells , with tag free.
KBTBD8 serves as a substrate-specific adapter within the BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex, functioning as a crucial regulator of neural crest specification. The BCR(KBTBD8) complex orchestrates this regulatory role by mediating the monoubiquitination of NOLC1 and TCOF1. Monoubiquitination facilitates the formation of a NOLC1-TCOF1 complex, serving as a platform that connects RNA polymerase I with enzymes responsible for ribosomal processing and modification. This orchestrated interaction leads to the remodeling of the translational program in differentiating cells, favoring neural crest specification. As a component of the BCR(KBTBD8) E3 ubiquitin ligase complex, alongside CUL3 and RBX1, KBTBD8 plays a pivotal role in modulating cellular processes involved in neural crest development.
Technical Parameters
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Species Human
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Source Sf9 insect cells
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Tag Tag Free
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Accession
Q8NFY9 (A2-L601)
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Gene ID84541
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Molecular Construction
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N-term
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KBTBD8 (A2-L601)
Accession # Q8NFY9 -
C-term
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Protein Length
Partial
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Synonyms
KBTBD8; KIAA1842; Kelch Repeat And BTB Domain Containing 8; Kelch Repeat And BTB Domain-Containing Protein 8; TA-KRP; Kelch Repeat And BTB (POZ) Domain Containing 8; T-Cell Activation Kelch Repeat Protein; TAKRP
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AA Sequence
AASADLSKSSPTPNGIPSSDPASDAMDPFHACSILKQLKTMYDEGQLTDIVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYAYTSRVILTEANVQALFTAASIFQIPSIQDQCAKYMISHLDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQNEREVHLPEIFAKCIRFPLMEDTFIEKIPPQFAQAIAKSCVEKGPSNTNGCTQRLGMTASEMIICFDAAHKHSGKKQTVPCLDIVTGRVFKLCKPPNDLREVGILVSPDNDIYIAGGYRPSSSEVSIDHKAENDFWMYDHSTNRWLSKPSLLRARIGCKLVYCCGKMYAIGGRVYEGDGRNSLKSVECYDSRENCWTTVCAMPVAMEFHNAVEYKEKIYVLQGEFFLFYEPQKDYWGFLTPMTVPRIQGLAAVYKDSIYYIAGTCGNHQRMFTVEAYDIELNKWTRKKDFPCDQSINPYLKLVLFQNKLHLFVRATQVTVEEHVFRTSRKNSLYQYDDIADQWMKVYETPDRLWDLGRHFECAVAKLYPQCLQKVL
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Solution.
<1 EU/μg, determined by LAL method.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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