LRIG1 Protein, Mouse (HEK293, His)
The LRIG1 protein acts as a negative feedback regulator of receptor tyrosine kinase signaling by promoting receptor ubiquitination and accelerating intracellular degradation.Its extracellular LRR and Ig-like domains can interact with EGFR/ERBB1, ERBB2, ERBB3 and ERBB4.LRIG1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived LRIG1 protein, expressed by HEK293 , with C-6*His labeled tag.
- Species: Mouse
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
The LRIG1 protein acts as a negative feedback regulator of receptor tyrosine kinase signaling by promoting receptor ubiquitination and accelerating intracellular degradation.Its extracellular LRR and Ig-like domains can interact with EGFR/ERBB1, ERBB2, ERBB3 and ERBB4.LRIG1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived LRIG1 protein, expressed by HEK293 , with C-6*His labeled tag.
Background
LRIG1 Protein acts as a feedback negative regulator of signaling by receptor tyrosine kinases, enhancing receptor ubiquitination and accelerating intracellular degradation. It interacts with EGFR/ERBB1, ERBB2, ERBB3, and ERBB4 through its extracellular LRR and Ig-like domains. The physiological relevance of this interaction is controversial, as LRIG1 may have low affinity for EGFR and the interaction may only occur when both proteins are present at high levels.
Technical Parameters
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Species Mouse
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Source HEK293
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Tag C-6*His
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Accession
P70193 (A35-T794)
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Molecular Construction
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N-term
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LRIG1 (A35-T794)
Accession # P70193 -
6*His
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C-term
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Protein Length
Extracellular Domain
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Synonyms
LRIG1; Leucine-Rich Repeat Protein LRIG1; Leucine Rich Repeats And Immunoglobulin Like Domains 1; Leucine-Rich Repeats And Immunoglobulin-Like Domains Protein 1; LIG-1; Ortholog Of Mouse Integral Membrane Glycoprotein LIG-1; LIG1; DKFZP586O1624
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AA Sequence
AQAGPRAPCAAACTCAGDSLDCSGRGLATLPRDLPSWTRSLNLSYNRLSEIDSAAFEDLTNLQEVYLNSNELTAIPSLGAASIGVVSLFLQHNKILSVDGSQLKSYLSLEVLDLSSNNITEIRSSCFPNGLRIRELNLASNRISILESGAFDGLSRSLLTLRLSKNRITQLPVKAFKLPRLTQLDLNRNRIRLIEGLTFQGLDSLEVLRLQRNNISRLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSISRIQRDGWSFCQKLHELILSFNNLTRLDEESLAELSSLSILRLSHNAISHIAEGAFKGLKSLRVLDLDHNEISGTIEDTSGAFTGLDNLSKLTLFGNKIKSVAKRAFSGLESLEHLNLGENAIRSVQFDAFAKMKNLKELYISSESFLCDCQLKWLPPWLMGRMLQAFVTATCAHPESLKGQSIFSVLPDSFVCDDFPKPQIITQPETTMAVVGKDIRFTCSAASSSSSPMTFAWKKDNEVLANADMENFAHVRAQDGEVMEYTTILHLRHVTFGHEGRYQCIITNHFGSTYSHKARLTVNVLPSFTKIPHDIAIRTGTTARLECAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIDDMGVYSCTAQNSAGSVSANATLTVLETPSLAVPLEDRVVTVGETVAFQCKATGSPTPRITWLKGGRPLSLTERHHFTPGNQLLVVQNVMIDDAGRYTCEMSNPLGTERAHSQLSILPTPGCRKDGTT
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Predicted Molecular Mass
84.5 kDa
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Molecular Weight
Approximately 94 kDa, based on SDS-PAGE under reducing conditions.
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Glycosylation
Yes
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US;may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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