LRRC15 Protein, Cynomolgus/Rhesus macaque (HEK293, His)
LRRC15 is a cell membrane-expressed protein belonging to the LRR superfamily. Involved in cell-cell and cell-ECM interactions. The LRRC15 protein regulates the infectivity of SARS-CoV-2 by interacting with its spike protein. LRRC15 activates the β1-integrin /FAK signaling pathway to promote ovarian cancer metastasis. LRRC15 Protein, Cynomolgus/Rhesus macaque (HEK293, His) is the recombinant cynomolgus-derived LRRC15 protein, expressed by HEK293 , with C-His labeled tag.
- Species: Rhesus Macaque; Cynomolgus
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- References
- Help & FAQs
Biological Activity
Description
LRRC15 is a cell membrane-expressed protein belonging to the LRR superfamily. Involved in cell-cell and cell-ECM interactions. The LRRC15 protein regulates the infectivity of SARS-CoV-2 by interacting with its spike protein. LRRC15 activates the β1-integrin /FAK signaling pathway to promote ovarian cancer metastasis. LRRC15 Protein, Cynomolgus/Rhesus macaque (HEK293, His) is the recombinant cynomolgus-derived LRRC15 protein, expressed by HEK293 , with C-His labeled tag.
Background
LRRC15 is a cell membrane-expressed protein belonging to the LRR superfamily. Involved in cell-cell and cell-ECM interactions. The LRRC15 protein regulates the infectivity of SARS-CoV-2 by interacting with its spike protein. It does not act as an entry receptor for SARS-CoV-2, but when it is expressed on nearby cells, it isolates virions and trans inhibits SARS-CoV-2 infection of ACE2 (+) cells. In addition, the LRRC15 protein directly interacts with the RBD domain of the human coronavirus SARS-CoV-2 spike protein, resulting in the isolation of virions on the cell surface. LRRC15 activates the β1-integrin /FAK signaling pathway to promote ovarian cancer metastasis, and the LRRC15-targeted antiboy-drug conjugate ABBV-085 was found to inhibit ovarian cancer metastasis in preclinical models[1][2][3].
Technical Parameters
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Species Rhesus Macaque; Cynomolgus
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Source HEK293
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Tag C-8*His
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Accession
G7NYR2/F7FSB9 (Y22-G538)
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Molecular Construction
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N-term
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LRRC15 (Y22-G538)
Accession # G7NYR2/F7FSB9 -
8*His
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C-term
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Protein Length
Extracellular Domain
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Synonyms
LRRC15; Leucine-Rich Repeat-Containing Protein 15; Leucine Rich Repeat Containing 15; HLib; LIB; Leucine-Rich Repeat Protein Induced By Beta Amyloid; Leucine-Rich Repeat Protein Induced By Beta-Amyloid Homolog
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AA Sequence
YYGCPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELSESPFLNISALIALRIEKNELSHIMPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLVQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSPGIFGPMPNLRELWLYDNHITSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMTIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQSLIIINVNVAVPSVHVPEVPSYPETSWYPDTSSYPDTTSISSTTELTSPVEDYTDLTTIQVTDDRSVWGMTQAQSG
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Predicted Molecular Mass
58.9 kDa
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Molecular Weight
Approximately 70-90 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
References
[1]. Ray U, et al. Exploiting LRRC15 as a Novel Therapeutic Target in Cancer. Cancer Res. 2022 May 3;82(9):1675-1681. [Content Brief]
[2]. Berkowitz RL, et al. The Elusive Coreceptors for the SARS-CoV-2 Spike Protein. Viruses. 2022 Dec 25;15(1):67. [Content Brief]
[3]. Ray U, et al. Targeting LRRC15 Inhibits Metastatic Dissemination of Ovarian Cancer. Cancer Res. 2022 Mar 15;82(6):1038-1054. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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