LTK Protein, Mouse (HEK293, His)
LTK Protein, Mouse (HEK293, His) is the recombinant mouse-derived LTK protein, expressed by HEK293, with C-His tag.
- Species: Mouse
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
LTK Protein, Mouse (HEK293, His) is the recombinant mouse-derived LTK protein, expressed by HEK293, with C-His tag.
LTK protein, possessing tyrosine-protein kinase activity, is activated by ALKAL1 or ALKAL2 ligands, transducing extracellular signals into intracellular responses. Upon ligand binding at the cell surface, the receptor undergoes tyrosine kinase activation, leading to the initiation of the mitogen-activated protein kinase (MAPK) pathway. Notably, LTK phosphorylates predominantly at the first tyrosine of the Y-x-x-x-Y-Y motif. While the precise function of LTK remains unclear, chimeric protein studies suggest its capacity to promote growth, specifically neurite outgrowth, and cell survival. Additionally, LTK is implicated in the regulation of the secretory pathway, influencing endoplasmic reticulum export sites (ERESs) and ER to Golgi transport.
Technical Parameters
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Species Mouse
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Source HEK293
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Tag C-8*His
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Accession
P08923 (I17-P421)
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Gene ID4058
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Protein Length
Extracellular Domain
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Synonyms
LTK; Protein Tyrosine Kinase 1; Leukocyte Receptor Tyrosine Kinase; Receptor Protein-Tyrosine Kinase; TYK1; Tyrosine-Protein Kinase Receptor; Leukocyte Tyrosine Kinase Receptor; Leukocyte Tyrosine Kinase
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AA Sequence
ILCSNSEFQTPFLTPSLLPVLVLNSQEQKVTPTPSKLEPASLPNPLGTRGPWVFNTCGASGRSGPTQTQCDGAYTGSSVMVTVGAAGPLKGVQLWRVPDTGQYLISAYGAAGGKGAQNHLSRAHGIFLSAVFFLRRGEPVYILVGQQGQDACPGGSPESQLVCLGESGEHATTYGTERIPGWRRWAGGGGGGGGATSIFRLRAGEPEPLLVAAGGGGRSYRRRPDRGRTQAVPERLETRAAAPGSGGRGGAAGGGSGWTSRAHSPQAGRSPREGAEGGEGCAEAWAALRWAAAGGFGGGGGACAAGGGGGGYRGGDTSESDLLWADGEDGTSFVHPSGELYLQPLAVTEGHGEVEIRKHPNCSHCPFKDCQWQAELWTAECTCPEGTELAVDNVTCMDLPTTASP
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Predicted Molecular Mass
42.6 kDa
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Molecular Weight
Approximately 50-65 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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