MAVS Protein, Human (His-SUMO)
Based on 1 Customer Validation
MAVS Protein, Human (His-SUMO) is the recombinant human-derived MAVS, expressed by E. coli , with N-6*His, N-SUMO labeled tag. ,
- Species: Human
- Source: E. coli
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
MAVS Protein, Human (His-SUMO) is the recombinant human-derived MAVS, expressed by E. coli , with N-6*His, N-SUMO labeled tag. ,
Background
MAVS is an adapter protein required for innate immune defense against viruses, acting downstream of DHX33, RIGI, and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication. It coordinates pathways leading to the activation of NF-kappa-B, IRF3, and IRF7, subsequently inducing antiviral cytokines such as IFNB and RANTES (CCL5). Peroxisomal and mitochondrial MAVS act sequentially to establish an antiviral cellular state: upon viral infection, peroxisomal MAVS rapidly induces interferon-independent expression of defense factors for short-term protection, while mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics to amplify and stabilize the antiviral response. MAVS may also activate the same pathways following detection of extracellular dsRNA by TLR3 and may protect cells from apoptosis. Additionally, MAVS is involved in NLRP3 inflammasome activation by mediating NLRP3 recruitment to mitochondria.
Technical Parameters
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Species Human
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Source E. coli
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Tag N-6*His;N-SUMO
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Accession
Q7Z434-1 (M1-P513)
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Gene ID/
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Protein Length
Cytoplasmic Domain
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Synonyms
MAVS; Mitochondrial Antiviral-Signaling Protein; Mitochondrial Antiviral Signaling Protein; CARD Adapter Inducing Interferon Beta; Cardif; Virus-Induced Signaling Adaptor; IPS-1; Virus-Induced-Signaling Adapter; VISA; CARD Adaptor Inducing IFN-Beta; KIAA1
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AA Sequence
MPFAEDKTYKYICRNFSNFCNVDVVEILPYLPCLTARDQDRLRATCTLSGNRDTLWHLFNTLQRRPGWVEYFIAALRGCELVDLADEVASVYQSYQPRTSDRPPDPLEPPSLPAERPGPPTPAAAHSIPYNSCREKEPSYPMPVQETQAPESPGENSEQALQTLSPRAIPRNPDGGPLESSSDLAALSPLTSSGHQEQDTELGSTHTAGATSSLTPSRGPVSPSVSFQPLARSTPRASRLPGPTGSVVSTGTSFSSSSPGLASAGAAEGKQGAESDQAEPIICSSGAEAPANSLPSKVPTTLMPVNTVALKVPANPASVSTVPSKLPTSSKPPGAVPSNALTNPAPSKLPINSTRAGMVPSKVPTSMVLTKVSASTVPTDGSSRNEETPAAPTPAGATGGSSAWLDSSSENRGLGSELSKPGVLASQVDSPFSGCFEDLAISASTSLGMGPCHGPEENEYKSEGTFGIHVAENPSIQLLEGNPGPPADPDGGPRPQADRKFQEREVPCHRPSP
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Predicted Molecular Mass
66.4 kDa
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Molecular Weight
Approximately 70-90 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 85%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder
Lyophilized from a 0.22 μm filtered solution of PBS, 6% trehalose, pH 7.4.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
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Data Sheet (238 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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