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MBIP Protein, Human (His)

Cat. No.: HY-P70921
Handling Instructions

MBIP protein inhibits MAP3K12 activity and prevents activation of the JNK/SAPK pathway. It is an important component of the ATAC complex, a histone acetyltransferase complex targeting histones H3 and H4. MBIP Protein, Human (His) is the recombinant human-derived MBIP protein, expressed by E. coli , with N-6*His labeled tag. The total length of MBIP Protein, Human (His) is 344 a.a., with molecular weight of ~50.0 kDa.

For research use only. We do not sell to patients.

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Description

MBIP protein inhibits MAP3K12 activity and prevents activation of the JNK/SAPK pathway. It is an important component of the ATAC complex, a histone acetyltransferase complex targeting histones H3 and H4. MBIP Protein, Human (His) is the recombinant human-derived MBIP protein, expressed by E. coli , with N-6*His labeled tag. The total length of MBIP Protein, Human (His) is 344 a.a., with molecular weight of ~50.0 kDa.

Background

MBIP protein exerts its inhibitory role by suppressing the activity of MAP3K12, thereby preventing the activation of the JNK/SAPK pathway. Additionally, MBIP serves as a crucial component of the ATAC complex, a histone acetyltransferase complex with activity on histones H3 and H4. Within the ADA2A-containing complex (ATAC), MBIP collaborates with other components, including KAT14, KAT2A, TADA2L, TADA3L, ZZ3, WDR5, YEATS2, CCDC101, and DR1. In this intricate complex, MBIP is likely to engage in direct interactions with KAT2A, KAT14, and WDR5, highlighting its integral role in chromatin modification processes.

Species

Human

Source

E. coli

Tag

N-6*His

Accession

Q9NS73 (M1-P344)

Gene ID
Molecular Construction
N-term
6*His
MBIP (M1-P344)
Accession # Q9NS73
C-term
Synonyms
MAP3K12-Binding Inhibitory Protein 1; MAPK Upstream Kinase-Binding Inhibitory Protein; MUK-Binding Inhibitory Protein; MBIP
AA Sequence

MAAATELNRPSSGDRNLERRCRPNLSREVLYEIFRSLHTLVGQLDLRDDVVKITIDWNKLQSLSAFQPALLFSALEQHILYLQPFLAKLQSPIKEENTTAVEEIGRTEMGNKNEVNDKFSIGDLQEEEKHKESDLRDVKKTQIHFDPEVVQIKAGKAEIDRRISAFIERKQAEINENNVREFCNVIDCNQENSCARTDAIFTPYPGFKSHVKVSRVVNTYGPQTRPEGIPGSGHKPNSMLRDCGNQAVEERLQNIEAHLRLQTGGPVPRDIYQRIKKLEDKILELEGISPEYFQSVSFSGKRRKVQPPQQNYSLAELDEKISALKQALLRKSREAESMATHHLP

Molecular Weight

Approximately 50.0 kDa

Purity

Greater than 95% as determined by reducing SDS-PAGE.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation

MBIP Protein, Human (His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Product Name:
MBIP Protein, Human (His)
Cat. No.:
HY-P70921
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