MBIP Protein, Human (His)

MBIP protein inhibits MAP3K12 activity and prevents activation of the JNK/SAPK pathway. It is an important component of the ATAC complex, a histone acetyltransferase complex targeting histones H3 and H4. MBIP Protein, Human (His) is the recombinant human-derived MBIP protein, expressed by E. coli , with N-6*His labeled tag.

MBIP protein exerts its inhibitory role by suppressing the activity of MAP3K12, thereby preventing the activation of the JNK/SAPK pathway. Additionally, MBIP serves as a crucial component of the ATAC complex, a histone acetyltransferase complex with activity on histones H3 and H4. Within the ADA2A-containing complex (ATAC), MBIP collaborates with other components, including KAT14, KAT2A, TADA2L, TADA3L, ZZ3, WDR5, YEATS2, CCDC101, and DR1. In this intricate complex, MBIP is likely to engage in direct interactions with KAT2A, KAT14, and WDR5, highlighting its integral role in chromatin modification processes.

Human

E. coli

N-6*His

Q9NS73-1 (M1-P344)

51562  [NCBI]

Full Length of Isoform-1

MAAATELNRPSSGDRNLERRCRPNLSREVLYEIFRSLHTLVGQLDLRDDVVKITIDWNKLQSLSAFQPALLFSALEQHILYLQPFLAKLQSPIKEENTTAVEEIGRTEMGNKNEVNDKFSIGDLQEEEKHKESDLRDVKKTQIHFDPEVVQIKAGKAEIDRRISAFIERKQAEINENNVREFCNVIDCNQENSCARTDAIFTPYPGFKSHVKVSRVVNTYGPQTRPEGIPGSGHKPNSMLRDCGNQAVEERLQNIEAHLRLQTGGPVPRDIYQRIKKLEDKILELEGISPEYFQSVSFSGKRRKVQPPQQNYSLAELDEKISALKQALLRKSREAESMATHHLP

Approximately 50 kDa,based on SDS-PAGE under reducing conditions.

≥ 95%, as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.