MBIP Protein, Human (His)
MBIP protein inhibits MAP3K12 activity and prevents activation of the JNK/SAPK pathway. It is an important component of the ATAC complex, a histone acetyltransferase complex targeting histones H3 and H4. MBIP Protein, Human (His) is the recombinant human-derived MBIP protein, expressed by E. coli , with N-6*His labeled tag.
- Species: Human
- Source: E. coli
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
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Biological Activity
Description
MBIP protein inhibits MAP3K12 activity and prevents activation of the JNK/SAPK pathway. It is an important component of the ATAC complex, a histone acetyltransferase complex targeting histones H3 and H4. MBIP Protein, Human (His) is the recombinant human-derived MBIP protein, expressed by E. coli , with N-6*His labeled tag.
Background
MBIP protein exerts its inhibitory role by suppressing the activity of MAP3K12, thereby preventing the activation of the JNK/SAPK pathway. Additionally, MBIP serves as a crucial component of the ATAC complex, a histone acetyltransferase complex with activity on histones H3 and H4. Within the ADA2A-containing complex (ATAC), MBIP collaborates with other components, including KAT14, KAT2A, TADA2L, TADA3L, ZZ3, WDR5, YEATS2, CCDC101, and DR1. In this intricate complex, MBIP is likely to engage in direct interactions with KAT2A, KAT14, and WDR5, highlighting its integral role in chromatin modification processes.
Technical Parameters
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Species Human
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Source E. coli
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Tag N-6*His
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Accession
Q9NS73-1 (M1-P344)
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Molecular Construction
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N-term
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6*His
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MBIP (M1-P344)
Accession # Q9NS73-1 -
C-term
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Protein Length
Full Length of Isoform-1
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Synonyms
MBIP; MUK-Binding Inhibitory Protein; MAP3K12 Binding Inhibitory Protein 1; CDNA, FLJ96307, Homo Sapiens MAP3K12 Binding Inhibitory Protein 1 (MBIP), MRNA; MAPK Upstream Kinase-Binding Inhibitory Protein; MAP3K12 Binding Inhibitory Protein 1, Isoform CRA_
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AA Sequence
MAAATELNRPSSGDRNLERRCRPNLSREVLYEIFRSLHTLVGQLDLRDDVVKITIDWNKLQSLSAFQPALLFSALEQHILYLQPFLAKLQSPIKEENTTAVEEIGRTEMGNKNEVNDKFSIGDLQEEEKHKESDLRDVKKTQIHFDPEVVQIKAGKAEIDRRISAFIERKQAEINENNVREFCNVIDCNQENSCARTDAIFTPYPGFKSHVKVSRVVNTYGPQTRPEGIPGSGHKPNSMLRDCGNQAVEERLQNIEAHLRLQTGGPVPRDIYQRIKKLEDKILELEGISPEYFQSVSFSGKRRKVQPPQQNYSLAELDEKISALKQALLRKSREAESMATHHLP
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Predicted Molecular Mass
42.5 kDa
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Molecular Weight
Approximately 43 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US;may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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