MBIP - MAP3K12 binding inhibitory protein 1 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51562

About MBIP

Cytogenetic location: 14q13.3 Genomic coordinates (GRCh38): 14:36,298,564-36,320,637 (from NCBI)

This gene has 10 transcripts (splice variants), 197 orthologues and 3 paralogues. Broad expression in thyroid (RPKM 34.1), lung (RPKM 32.4) and 24 other tissues.

Summary

Enables identical protein binding activity and protein kinase inhibitor activity. Involved in histone H3 acetylation; positive regulation of JNK cascade; and positive regulation of gene expression. Located in cytosol; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

MBIP Products (3)

mRNA Protein Name
NM_001144891.2 NP_001138363.1 MAP3K12-binding inhibitory protein 1 isoform 2
NM_001308110.2 NP_001295039.1 MAP3K12-binding inhibitory protein 1 isoform 3
NM_016586.3 NP_057670.2 MAP3K12-binding inhibitory protein 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
enables protein kinase inhibitor activity IDA
IDA: Inferred from direct assay
10801814 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
18838386 GOA
involved in positive regulation of JNK cascade IDA
IDA: Inferred from direct assay
10801814 GOA
involved in positive regulation of gene expression IDA
IDA: Inferred from direct assay
32963352 GOA
involved in regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
19936620 GOA
involved in regulation of cell cycle IMP
IMP: Inferred from mutant phenotype
19103755 GOA
involved in regulation of cell division IDA
IDA: Inferred from direct assay
20562830 GOA
involved in regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
22055187 GOA
involved in regulation of tubulin deacetylation IMP
IMP: Inferred from mutant phenotype
20562830 GOA
Cellular Component GO Annotation Evidence References Source
part of ATAC complex IDA
IDA: Inferred from direct assay
18838386 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

MAP3K12-binding inhibitory protein 1

  • MAPK upstream kinase-binding inhibitory protein

MBIP Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MBIP Q9NS73 EGFR Homo sapiens P00533
Ub Reconstruction
27956147
Intra
MBIP Q9NS73 EGFR Homo sapiens P00533
Anti Tag CoIP
27956147
Intra
MBIP Q9NS73 WDR5 Homo sapiens P61964
Anti Tag CoIP
33961781
Intra
MBIP Q9NS73 TXLNB Homo sapiens Q8N3L3
Y2H Array
31515488
Intra
MBIP Q9NS73 KAT14 Homo sapiens Q9H8E8
Anti Tag CoIP
33961781
Intra
MBIP Q9NS73 KAT14 Homo sapiens Q9H8E8
Y2H Pooling
16189514
Intra
MBIP Q9NS73 SGF29 Homo sapiens Q96ES7
Anti Tag CoIP
33961781
Intra
MBIP Q9NS73 PLEKHF2 Homo sapiens Q9H8W4
Y2H Pooling
16189514
Intra
MBIP Q9NS73 PLEKHF2 Homo sapiens Q9H8W4
Y2H Array
19060904
Intra
MBIP Q9NS73 PLEKHF2 Homo sapiens Q9H8W4
Y2H Pooling
19060904
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant MBIP Proteins

Cat. No. Product Name Accession Purity
HY-P70921 MBIP Protein, Human (His) Q9NS73-1 (M1-P344) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Bronchus Adenoma

  • Bronchial Adenoma

  • Adenoma Of The Bronchus
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06433 Hspa5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08187 MBIP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20295 Mbip Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26803 Mbip Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus MBIP MGD MGI:1918320
Bos taurus MBIP VGNC VGNC:31279
Felis catus MBIP VGNC VGNC:80921
Canis familiaris MBIP VGNC VGNC:43055
Macaca mulatta MBIP VGNC VGNC:74543
Rattus norvegicus MBIP RGD RGD:1306310
Others MBIP NCBI