2. Protéines recombinantes
  3. Immune Checkpoint Proteins CD Antigens Receptor Proteins
  4. Inhibitory Checkpoint Molecules NK Cell CD Proteins Platelet CD Proteins Erythrocyte CD Proteins Epithelial cell CD Proteins Endothelial cell CD Proteins Cell Adhesion Molecules (CAMs)
  5. Nectin-1/CD111 Immunoglobulin-like Cell Adhesion Molecules
  6. Nectin-1 Protein, Human (HEK293, His-Avi)

Nectin-1 Protein mediates cell-cell contacts through homophilic or heterophilic trans-dimer formation, engaging in heterophilic interactions with Nectin-3 and Nectin-4. It also promotes neurite outgrowth. In microbial infection, Nectin-1 serves as a receptor for herpes simplex virus 1 (HHV-1), herpes simplex virus 2 (HHV-2), and pseudorabies virus (PRV). Nectin-1 Protein, Human (HEK293, His-Avi) is the recombinant human-derived Nectin-1 protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

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Description

Nectin-1 Protein mediates cell-cell contacts through homophilic or heterophilic trans-dimer formation, engaging in heterophilic interactions with Nectin-3 and Nectin-4. It also promotes neurite outgrowth. In microbial infection, Nectin-1 serves as a receptor for herpes simplex virus 1 (HHV-1), herpes simplex virus 2 (HHV-2), and pseudorabies virus (PRV). Nectin-1 Protein, Human (HEK293, His-Avi) is the recombinant human-derived Nectin-1 protein, expressed by HEK293 , with C-Avi, C-His labeled tag.
Background

The Nectin-1 Protein facilitates cell-cell contacts through the formation of homophilic or heterophilic trans-dimers. It is known to engage in heterophilic interactions with Nectin-3 and Nectin-4. Additionally, this protein exhibits neurite outgrowth-promoting activity. In the context of microbial infection, Nectin-1 acts as a receptor for herpes simplex virus 1 (HHV-1), herpes simplex virus 2 (HHV-2), and pseudorabies virus (PRV).
Species

Human
Source

HEK293
Tag

C-Avi;C-8*His
Accession

Q15223-1 (Q31-T334)
Gene ID
Molecular Construction
N-term
Nectin-1 (Q31-T334)
Accession # Q15223-1
8*His-Avi
C-term
Protein Length

Partial
Synonyms
CD111; ED4; HIgRPVRR; HVEC; MGC142031; Nectin1; PRR; PRR1; PRR1MGC16207; PVRL1; PVRR1; SK-12; PVRL1; CLPED1; HIgR; OFC7; PVRR
AA Sequence

QVVQVNDSMYGFIGTDVVLHCSFANPLPSVKITQVTWQKSTNGSKQNVAIYNPSMGVSVLAPYRERVEFLRPSFTDGTIRLSRLELEDEGVYICEFATFPTGNRESQLNLTVMAKPTNWIEGTQAVLRAKKGQDDKVLVATCTSANGKPPSVVSWETRLKGEAEYQEIRNPNGTVTVISRYRLVPSREAHQQSLACIVNYHMDRFKESLTLNVQYEPEVTIEGFDGNWYLQRMDVKLTCKADANPPATEYHWTTLNGSLPKGVEAQNRTLFFKGPINYSLAGTYICEATNPIGTRSGQVEVNIT

Predicted Molecular Mass
36.9 kDa
Masse moléculaire

Approximately 52-70 kDa,based on SDS-PAGE under reducing conditions,due to the glycosylation.
Glycosylation
Yes
Pureté

≥ 95%, as determined by Bis-Tris PAGE.
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Instruction de manipulation (2659 KB)

Nectin-1 Protein, Human (HEK293, His-Avi) Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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