Nectin-4 Protein, Cynomolgus (HEK293, hFc)
Nectin-4 Protein, Cynomolgus (HEK293, hFc) is the recombinant cynomolgus-derived Nectin-4 protein, expressed by HEK293, with C-hFc tag.
- Species: Cynomolgus
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
Nectin-4 Protein, Cynomolgus (HEK293, hFc) is the recombinant cynomolgus-derived Nectin-4 protein, expressed by HEK293, with C-hFc tag.
Background
The Nectin-4 protein belongs to the nectin family, a group of cell adhesion molecules involved in various cellular processes. Nectin-4 plays a significant role in cell-cell adhesion and is primarily expressed in epithelial tissues. It functions through interactions with other nectin family members and integrins, contributing to the formation and maintenance of cell junctions. Nectin-4 is particularly important in the development and integrity of epithelial tissues, including the skin, lungs, and mammary glands. It is also implicated in cancer progression, as it promotes tumor cell invasion and metastasis. Understanding the role of Nectin-4 in normal physiology and disease pathology can provide valuable insights into potential therapeutic approaches for conditions involving epithelial tissue dysfunction or cancer.
Technical Parameters
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Species Cynomolgus
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Source HEK293
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Tag C-hFc
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Accession
XP_005541277.1 (G32-S349)
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Gene ID102127936
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Protein Length
Partial
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Synonyms
NECTIN4; Poliovirus Receptor-Related Protein 4; Prev. PVRL4; Poliovirus Receptor-Related 4; Nectin-4; Nectin 4; PRR4; EDSS1; LNIR; Nectin Cell Adhesion Molecule 4; Ig Superfamily Receptor LNIR
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AA Sequence
GELETSDVVTVVLGQDAKLPCFYRGDSGEQVGQVAWARADAGEGAQELALLHSKYGLHVSPAYEGRVEQPPPPRNPLDGSVLLRNAVQADEGEYECRVSTFPAGSFQARLRLRVLVPPLPSLNPGPALEEGQGLTLAASCTAEGSPAPSVTWDTEVKGTTSSRSFKHSRSAAVTSEFHLVPSRSMNGQPLTCVVSHPGLLQDQRITHILHVSFLAEASVRGLEDQNLWHVGREGAMLKCLSEGQPPPSYNWTRLDGPLPSGVRVDGDTLGFPPLTTEHSGIYVCHVSNEFSSRDSQVTVDVLDPQEDSGKQVDLVSAS
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Predicted Molecular Mass
60.8 kDa
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Molecular Weight
Approximately 65-73 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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