OGN/Osteoglycin Protein, Mouse (HEK293, His)
Based on 1 publication(s) in Google Scholar
OGN/Osteoglycin protein collaborates with TGF-beta-1 or TGF-beta-2 to regulate bone formation. It interacts synergistically with specific isoforms of TGF-beta, modulating bone development and remodeling. This highlights OGN's significance in bone homeostasis and its potential as a therapeutic target for bone-related conditions. OGN/Osteoglycin Protein, Mouse (HEK293, His) is the recombinant mouse-derived OGN/Osteoglycin protein, expressed by HEK293 , with C-6*His labeled tag.
- Species: Mouse
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
OGN/Osteoglycin protein collaborates with TGF-beta-1 or TGF-beta-2 to regulate bone formation. It interacts synergistically with specific isoforms of TGF-beta, modulating bone development and remodeling. This highlights OGN's significance in bone homeostasis and its potential as a therapeutic target for bone-related conditions. OGN/Osteoglycin Protein, Mouse (HEK293, His) is the recombinant mouse-derived OGN/Osteoglycin protein, expressed by HEK293 , with C-6*His labeled tag.
Background
OGN/Osteoglycin protein acts as a key regulator, inducing bone formation in collaboration with TGF-beta-1 or TGF-beta-2. This implies that OGN plays a pivotal role in modulating bone development and remodeling processes by synergistically interacting with specific isoforms of transforming growth factor-beta. The orchestrated interplay between OGN and TGF-beta signaling pathways underscores its significance in the intricate molecular mechanisms governing bone homeostasis and highlights its potential as a therapeutic target for conditions related to bone formation and maintenance.
Verified Bioactivity
Measured by its ability to modulate collagen fibrillogenesis. At 15 µg/mL, OGN can significantly retard the rate of type I collagen fibrillogenesis.
MCE Validation Data
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Purity - SDS-PAGE
Purity - SDS-PAGE
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Bioactivity - Biochemical Activity Assay
Bioactivity - Biochemical Activity Assay
Publications (1)
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Journal Impact Factor
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Most Recent
Technical Parameters
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Species Mouse
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Source HEK293
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Tag C-6*His
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Accession
Q62000 (A20-F298)
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Gene ID18295
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Molecular Construction
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N-term
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OGN (A20-F298)
Accession # Q62000 -
6*His
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C-term
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Protein Length
Full Length of Mature Protein
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Synonyms
OGN; Osteoinductive Factor; Osteoglycin; Mimecan Proteoglycan; Mimecan; Corneal Keratan Sulfate Proteoglycan; SLRR3A; Osteoglycin (Osteoinductive Factor); OIF; OG
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AA Sequence
APQSQLDSHVNYEYATGNSEETKFSQDYEDKYLDGKSIKEKETMIIPDEKSLQLQKDEVIPSLPTKKENDEMPTCLLCVCLSGSVYCEEVDIDAVPPLPKESAYLYARFNKIKKLTAKDFADMPNLRRLDFTGNLIEDIEDGTFSKLSLLEELTLAENQLLRLPVLPPKLTLLNAKHNKIKSKGIKANTFKKLNKLSFLYLDHNDLESVPPNLPESLRVIHLQFNSISSLTDDTFCKANDTRYIRERIEEIRLEGNPIALGKHPNSFICLKRLPIGSYF
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Molecular Weight
Approximately 50 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.
<0.1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
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Data Sheet (237 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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