OSM Protein, Mouse (HEK293, His)

OSM protein is a multifunctional growth regulator that effectively inhibits the proliferation of tumor cell lines and regulates the production of cytokines, including IL-6, G-CSF, and GM-CSF produced by endothelial cells. It specifically binds to type II OSM receptors, forming a heterodimer composed of OSMR and IL6ST. OSM Protein, Mouse (HEK293, His) is the recombinant mouse-derived OSM protein, expressed by HEK293 , with C-His labeled tag. The total length of OSM Protein, Mouse (HEK293, His) is 182 a.a., with molecular weight of 35-50 kDa.

OSM Protein emerges as a versatile growth regulator with a potent ability to inhibit the proliferation of various tumor cell lines. This multifaceted protein extends its influence to the regulation of cytokine production, including IL-6, G-CSF, and GM-CSF from endothelial cells. OSM exclusively engages the type II OSM receptor, forming heterodimers composed of OSMR and IL6ST. Beyond its antiproliferative effects, OSM is intricately involved in the maturation of fetal hepatocytes, playing a pivotal role in promoting both liver development and regeneration.

Mouse

HEK293

C-His

P53347 (N25-R206)

18413  [NCBI]

35-50 kDa

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized powder.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.