Osm - oncostatin M Gene

Also Known as OncoM

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18413

Summary

Enables cytokine activity. Acts upstream of or within several processes, including negative regulation of meiotic nuclear division; positive regulation of peptidyl-tyrosine phosphorylation; and tyrosine phosphorylation of STAT protein. Predicted to be located in extracellular space. Is expressed in several structures, including dorsal aorta; future spinal cord; liver; reproductive system; and submandibular gland. Orthologous to human OSM (oncostatin M). [provided by Alliance of Genome Resources, Apr 2022]

Osm Products (1)

mRNA Protein Name
NM_001013365.3 NP_001013383.1 oncostatin-M precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables cytokine activity IDA
IDA: Inferred from direct assay
15012602 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within behavioral response to pain IMP
IMP: Inferred from mutant phenotype
14985435 MGI
acts upstream of meiotic nuclear division IDA
IDA: Inferred from direct assay
11203703 MGI
acts upstream of or within negative regulation of meiotic nuclear division IDA
IDA: Inferred from direct assay
11203703 MGI
acts upstream of or within peripheral nervous system development IMP
IMP: Inferred from mutant phenotype
14985435 MGI
acts upstream of or within positive regulation of apoptotic signaling pathway IDA
IDA: Inferred from direct assay
15012602 MGI
acts upstream of or within positive regulation of peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
24129709 MGI
acts upstream of or within response to heat IMP
IMP: Inferred from mutant phenotype
14985435 MGI
acts upstream of or within tyrosine phosphorylation of STAT protein IDA
IDA: Inferred from direct assay
15012602 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

oncostatin-M

Recombinant Osm Proteins

Cat. No. Product Name Accession Purity
HY-P7274 OSM Protein, Mouse (HEK293) P53347 (A24-R206) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P7275 OSM Protein, Mouse P53347 (N25-R205) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P700805 OSM Protein, Mouse (HEK293, His) P53347 (N25-R206) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P99590 Sotatercept 99.94% Unkown

Clinical Phase

Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P99519 Vixarelimab Inhibitor 96.90% Phase 2
HY-P991051 GSK-2330811 Inhibitor 98.69% Phase 2

Pre-clinical Phase

Bioactive Molecules (13)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-33354 Nitrochin 99.92% Unkown
HY-148692 OSM-SMI-10B Inhibitor 99.70% Unkown
HY-175465 SMI-10B13 Inhibitor 99.30% Unkown
HY-162238 OSM-S-106 Inhibitor 99.34% Unkown
HY-148693 OSM-SMI-8 Antagonist / Unkown
HY-148693A (E/Z)-OSM-SMI-8 Antagonist / Unkown
HY-148692A (E/Z)-OSM-SMI-10B Inhibitor / Unkown
HY-148695B ADR58 sodium Inhibitor / Unkown
HY-148695C Truncated ADR58 sodium Inhibitor / Unkown
HY-RS02108 CCM2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09850 OSM Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16547 Osm Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22979 Osm Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991333 GSK-315234 Inhibitor 98.16% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Osm NCBI NCBI:5008