PDE6D Protein, Human (sf9, GST)
PDE6D Protein, Human (sf9, GST) is the recombinant human-derived PDE6D, expressed by Sf9 insect cells , with GST labeled tag. ,
- Species: Human
- Source: Sf9 insect cells
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
PDE6D Protein, Human (sf9, GST) is the recombinant human-derived PDE6D, expressed by Sf9 insect cells , with GST labeled tag. ,
Background
PDE6D promotes the release of prenylated target proteins from cellular membranes (PubMed:9712853). It modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location (PubMed:22002721, PubMed:23698361). PDE6D is required for normal ciliary targeting of farnesylated target proteins, such as INPP5E (PubMed:24166846). Additionally, it modulates the subcellular location of target proteins by acting as a GTP-specific dissociation inhibitor (GDI) (By similarity). PDE6D increases the affinity of ARL3 for GTP by several orders of magnitude and stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate (By similarity).
Technical Parameters
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Species Human
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Source Sf9 insect cells
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Tag GST
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Accession
O43924 (M1-V150)
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Gene ID5147
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Protein Length
Full Length
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Synonyms
PDE6D; GMP-PDE Delta; Phosphodiesterase 6D; Protein P17; Retinal Rod Rhodopsin-Sensitive CGMP 3',5'-Cyclic Phosphodiesterase Subunit Delta; PDED; JBTS22; Tmp_locus_12; Phosphodiesterase 6D, CGMP-Specific, Rod, Delta
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AA Sequence
MSAKDERAREILRGFKLNWMNLRDAETGKILWQGTEDLSVPGVEHEARVPKKILKCKAVSRELNFSSTEQMEKFRLEQKVYFKGQCLEEWFFEFGFVIPNSTNTWQSLIEAAPESQMMPASVLTGNVIIETKFFDDDLLVSTSRVRLFYV
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Molecular Weight
Approximately 43 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Solution.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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