PDE6D Protein, Human (sf9, GST)

PDE6D Protein, Human (sf9, GST) is the recombinant human-derived PDE6D, expressed by Sf9 insect cells , with GST labeled tag. ,

PDE6D promotes the release of prenylated target proteins from cellular membranes (PubMed:9712853). It modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location (PubMed:22002721, PubMed:23698361). PDE6D is required for normal ciliary targeting of farnesylated target proteins, such as INPP5E (PubMed:24166846). Additionally, it modulates the subcellular location of target proteins by acting as a GTP-specific dissociation inhibitor (GDI) (By similarity). PDE6D increases the affinity of ARL3 for GTP by several orders of magnitude and stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate (By similarity).

Human

Sf9 insect cells

GST

O43924 (M1-V150)

5147

Full Length

MSAKDERAREILRGFKLNWMNLRDAETGKILWQGTEDLSVPGVEHEARVPKKILKCKAVSRELNFSSTEQMEKFRLEQKVYFKGQCLEEWFFEFGFVIPNSTNTWQSLIEAAPESQMMPASVLTGNVIIETKFFDDDLLVSTSRVRLFYV

≥ 90%, as determined by reducing SDS-PAGE.