PRC1 Protein, Human (sf9, His)

PRC1, a pivotal regulator of cytokinesis, plays a crucial role in orchestrating the spatiotemporal formation of the midzone and ensuring successful cytokinesis by cross-linking antiparallel microtubules at an average distance of 35 nM. Its indispensability extends to the recruitment of key proteins such as KIF14, PLK1, and ECT2 to the central spindle and midbody, essential steps for proper cell division. In addition to its fundamental role in cellular processes, PRC1 exhibits oncogenic properties, promoting proliferation, inhibiting apoptosis, and contributing to the carcinogenic progression of bladder cancer cells. As a homodimer, PRC1 interacts with various proteins, including RACGAP1, CENPE, KIF4A, KIF23, and PLK1, forming a complex network of molecular interactions crucial for its multifaceted functions during mitosis. The intricate interplay of PRC1 with these proteins underscores its significance in the intricate machinery governing cell division and highlights its potential as a target for therapeutic interventions in cancer.