PRC1 - protein regulator of cytokinesis 1 Gene

Homo sapiens

Also known as ASE1

Gene ID: 9055 | Gene type: protein coding

About PRC1

Cytogenetic location: 15q26.1 Genomic coordinates (GRCh38): 15:90,966,040-90,994,535 (from NCBI)

This gene has 19 transcripts (splice variants) and 271 orthologues. Broad expression in bone marrow (RPKM 31.0), testis (RPKM 24.4) and 18 other tissues.

Summary

This gene encodes a protein that is involved in cytokinesis. The protein is present at high levels during the S and G2/M phases of mitosis but its levels drop dramatically when the cell exits mitosis and enters the G1 phase. It is located in the nucleus during interphase, becomes associated with mitotic spindles in a highly dynamic manner during mitosis, and localizes to the cell mid-body during cytokinesis. This protein has been shown to be a substrate of several cyclin-dependent kinases (CDKs). It is necessary for polarizing parallel microtubules and concentrating the factors responsible for contractile ring assembly. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]

PRC1 Products(3)

mRNA	Protein	Name
NM_001267580.2	NP_001254509.2	protein regulator of cytokinesis 1 isoform 4
NM_003981.4	NP_003972.2	protein regulator of cytokinesis 1 isoform 1
NM_199413.3	NP_955445.2	protein regulator of cytokinesis 1 isoform 2

PRC1 Protein Structure

MAP65_ASE1

0
100
200
300
400
500
620 a.a.

Protein Preferred Names

Protein Names

protein regulator of cytokinesis 1

anaphase spindle elongation 1 homolog

Recombinant PRC1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74620	PRC1 Protein, Human (sf9, His)	O43663 (M1-S620)	≥95%

Related Diseases

Diseases

Alias

Bladder Cancer

Urinary Bladder Cancer	Bladder Carcinoma
Urinary Bladder Carcinoma	Bladder Neoplasm
Bladder Tumor	Cancer, Bladder
Malignant Neoplasm Of Urinary Bladder	Carcinoma Of Bladder
Bladder Cancer, Somatic	Tumor Of The Bladder
Carcinoma Of Urinary Bladder	Bladder Carcinoma Urinary
Cancer Of The Urinary Bladder	Cancer, Urinary Bladder
Malignant Bladder Neoplasm	Malignant Bladder Tumor
Neoplasm Of The Bladder	Neoplasm Of The Urinary Bladder
Tumor Of The Urinary Bladder	Urinary Bladder Neoplasm
BLC	Urothelial Carcinoma Of The Bladder
Bladder Tumors	Urinary Bladder Neoplasms
Bladder Cancer Nos	Vesical Cancer Nos
Malignant Neoplasm Of Bladder, Part Unspecified	Malignant Tumour Of Urinary Bladder
Primary Malignant Neoplasm Of Bladder

Noonan Syndrome 3

NS3	Noonan Syndrome, Type 3

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-139514	RB-3	Inhibitor	99.42%	Unkown
HY-19817	PRT4165	Inhibitor	≥98.0%	Unkown
HY-RS11055	PRC1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PRC1	RGD	RGD:1311754
Canis familiaris	PRC1	VGNC	VGNC:44941
Macaca mulatta	PRC1	VGNC	VGNC:76389
Bos taurus	PRC1	VGNC	VGNC:33285
Mus musculus	PRC1	MGD	MGI:1858961
Felis catus	PRC1	VGNC	VGNC:69030
Others	PRC1	NCBI

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