PRC1 - protein regulator of cytokinesis 1 Gene

Also Known as ASE1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9055

About PRC1

Cytogenetic location: 15q26.1 Genomic coordinates (GRCh38): 15:90,966,040-90,994,535 (from NCBI)

This gene has 19 transcripts (splice variants) and 271 orthologues. Broad expression in bone marrow (RPKM 31.0), testis (RPKM 24.4) and 18 other tissues.

Summary

This gene encodes a protein that is involved in cytokinesis. The protein is present at high levels during the S and G2/M phases of Mitosis but its levels drop dramatically when the cell exits Mitosis and enters the G1 phase. It is located in the nucleus during interphase, becomes associated with mitotic spindles in a highly dynamic manner during Mitosis, and localizes to the cell mid-body during cytokinesis. This protein has been shown to be a substrate of several cyclin-dependent kinases (CDKs). It is necessary for polarizing parallel microtubules and concentrating the factors responsible for contractile ring assembly. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]

PRC1 Products (3)

mRNA Protein Name
NM_001267580.2 NP_001254509.2 protein regulator of cytokinesis 1 isoform 4
NM_003981.4 NP_003972.2 protein regulator of cytokinesis 1 isoform 1
NM_199413.3 NP_955445.2 protein regulator of cytokinesis 1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
16603632 GOA
enables kinesin binding IPI
IPI: Inferred from physical interaction
16431929 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
14744859 GOA
enables protein kinase binding IPI
IPI: Inferred from physical interaction
17351640 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
17409436 GOA
involved in regulation of cytokinesis IDA
IDA: Inferred from direct assay
17351640 GOA
Cellular Component GO Annotation Evidence References Source
located in contractile ring IDA
IDA: Inferred from direct assay
17409436 GOA
located in midbody IDA
IDA: Inferred from direct assay
17409436 GOA
located in nucleus IDA
IDA: Inferred from direct assay
17409436 GOA
located in spindle IDA
IDA: Inferred from direct assay
17351640 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRC1 Protein Structure

MAP65_ASE1

MAP65_ASE1: Microtubule associated protein (MAP65/ASE1 family) (37 - 615)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 620 a.a.
Protein Preferred Names Protein Names

protein regulator of cytokinesis 1

  • anaphase spindle elongation 1 homolog

PRC1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PRC1 O43663 MAT2A Homo sapiens P31153
Validated Y2H
32296183
Intra
PRC1 O43663 PKIA Homo sapiens P61925
Validated Y2H
32296183
Intra
PRC1 O43663 ACSM1 Homo sapiens Q08AH1
Anti Tag CoIP
28514442
Intra
PRC1 O43663 ACSM1 Homo sapiens Q08AH1
Anti Tag CoIP
33961781
Intra
PRC1 O43663 CINP Homo sapiens Q9BW66
Validated Y2H
32296183
Intra
PRC1 O43663 TRIM37 Homo sapiens O94972
Pull Down
16189514
Intra
PRC1 O43663 TRIM37 Homo sapiens O94972
Y2H Pooling
19447967
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PRC1 Proteins

Cat. No. Product Name Accession Purity
HY-P74620 PRC1 Protein, Human (sf9, His) O43663 (M1-S620) ≥ 95%, as determined by reducing SDS-PAGE.

PRC1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81968 Phospho-PRC1 (Thr481) Antibody (YA1713) WB, IHC-F, IHC-P, ICC/IF Human
HY-P81968A Phospho-PRC1 (Thr481) Antibody (YA1713)(PBS only) WB, IHC-F, IHC-P, ICC/IF Human
HY-P81971 PRC1 Antibody (YA1716) WB, IHC-P, IP Human, Rat
HY-P81971A PRC1 Antibody (YA1716)(PBS only) WB, IHC-P, IP Human, Rat

Related Diseases

Diseases Alias
Bladder Cancer

  • Urinary Bladder Cancer

  • Bladder Carcinoma

  • Urinary Bladder Carcinoma

  • Bladder Neoplasm

  • Bladder Tumor

  • Cancer, Bladder

  • Malignant Neoplasm Of Urinary Bladder

  • Carcinoma Of Bladder

  • Bladder Cancer, Somatic

  • Tumor Of The Bladder

  • Carcinoma Of Urinary Bladder

  • Bladder Carcinoma Urinary

  • Cancer Of The Urinary Bladder

  • Cancer, Urinary Bladder

  • Malignant Bladder Neoplasm

  • Malignant Bladder Tumor

  • Neoplasm Of The Bladder

  • Neoplasm Of The Urinary Bladder

  • Tumor Of The Urinary Bladder

  • Urinary Bladder Neoplasm

  • BLC

  • Urothelial Carcinoma Of The Bladder

  • Bladder Tumors

  • Urinary Bladder Neoplasms

  • Bladder Cancer Nos

  • Vesical Cancer Nos

  • Malignant Neoplasm Of Bladder, Part Unspecified

  • Malignant Tumour Of Urinary Bladder

  • Primary Malignant Neoplasm Of Bladder
Noonan Syndrome 3

  • NS3

  • Noonan Syndrome, Type 3
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (17)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-19817 PRT4165 Inhibitor 98.0% Unkown
HY-139514 RB-3 Inhibitor 99.14% Unkown
HY-138794 XL177A Inhibitor 99.60% Unkown
HY-170823 PRC1-IN-1 Inhibitor 97.30% Unkown
HY-158239 MS181 Inhibitor 98.36% Unkown
HY-159805 CDK2-IN-31 Inhibitor 98.22% Unkown
HY-P2254 H3K27(Me3) (15-34) 96.97% Unkown
HY-138794A (Rac)-XL177A Inhibitor / Unkown
HY-104023 ZK-Thiazolidinone Inhibitor / Unkown
HY-138794G XL177A (GMP) Inhibitor / Unkown
HY-158771 PRC1 ligand 1 Ligand / Unkown
HY-161521 PLK1-IN-10 Inhibitor / Unkown
HY-172943 PLK1/PRC1-IN-1 Inhibitor / Unkown
HY-179466 BKT300 / Unkown
HY-RS11055 PRC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16732 Prc1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23168 Prc1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PRC1 RGD RGD:1311754
Canis familiaris PRC1 VGNC VGNC:44941
Macaca mulatta PRC1 VGNC VGNC:76389
Bos taurus PRC1 VGNC VGNC:33285
Mus musculus PRC1 MGD MGI:1858961
Felis catus PRC1 VGNC VGNC:69030
Others PRC1 NCBI